What does Left Ventricular Dysfunction mean?
Left ventricular dysfunction (LVD) is a very common cardiac disorder which often leads to heart failure (or congestive heart failure). The major causes are ischemic heart disease, myocardial infarction, hypertension, cardiomyopathy, myocarditis, valve disease etc.
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Let’s first have a look at the normal physiology of heart. The left ventricle receives oxygenated blood from the left atrium which in turn receives the blood from the lungs. Due to dysfunction, the left ventricle is unable to function normally. Two types of dysfunction may occur- systolic dysfunction and diastolic dysfunction. Due to systolic dysfunction, the ventricle is unable to contract normally and heart is unable to pump enough blood throughout the body. Due to diastolic dysfunction, the ventricle is unable to relax normally, as a result of which it is unable to receive blood from the lungs. Left ventricular dysfunction can be the entire left ventricle (overall left ventricular dysfunction) or part of it (regional left ventricular dysfunction). Regional left ventricular dysfunction is more common in coronary artery disease, because of the local nature of the disease and can develop into more serious overall left ventricular dysfunction and dilatation, which is also known as left ventricular remodeling phenomenon.
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Sign & Symptom includes Cough with blood stained mucus, Fatigue, weakness, and shortness of breath, Palpitation, Rapid pulse, pulmonary edema and pleural effusion, Weight gain due to retention of fluid in the body, ascitis.
- reduce the heart rate;
- reduce the neurohormonal activation;
- enhance tissue and coronary perfusion;
- reduce the circulatory congestion;
- reduce the oxygen consumption;
- Restore cardiac size and shape;
- promote favorable cardiac and vascular remodeling;
Various medications which are used for symptomatological treatment- escitalopram, lorazepam are given to reduce anxiety and palpitation; ibuprofen, gabapentin for pain; Amitriptyline, Diphenhydramine for insomnia, iron infusion for fatigue; Venlafaxine for depressed mood etc.
Disclaimer: The information given in this write-up is purely for educating the reader. It is not meant to be a substitute for any advice from a medical expert.
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Global Markets Direct’s latest Pharmaceutical and Healthcare disease pipeline guide Left Ventricular Dysfunction – Pipeline Review, H1 2017, provides an overview of the Left Ventricular Dysfunction (Cardiovascular) pipeline landscape.
Left ventricular dysfunction is the most common cause of congestive heart failure. Symptoms include fluid retention, dizziness, fatigue, weakness, irregular heart beat and congested lungs. Risk factors include high blood pressure, diabetes, sleep apnea, alcoholism and coronary artery disease.
Global Markets Direct’s Pharmaceutical and Healthcare latest pipeline guide Left Ventricular Dysfunction – Pipeline Review, H1 2017, provides comprehensive information on the therapeutics under development for Left Ventricular Dysfunction (Cardiovascular), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.
The Left Ventricular Dysfunction (Cardiovascular) pipeline guide also reviews of key players involved in therapeutic development for Left Ventricular Dysfunction and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Phase III, Phase II and Phase I stages are 2, 7 and 2 respectively.
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