A Brief about Hidradenitis Suppurativa
Hidradenitis suppurativa or acne inversa, is a skin disease in which there are groups of abscesses or boil like infections especially in the under arms, inner thighs, under breasts, groin, buttocks etc. The disease has been known by various names throughout history- Acne conglobata, Verneuil’s disease, Acne inversa, Pyodermia fistulans significa, apocrine acne, Apocrinitis, Fox-den disease, Hidradenitis supportiva, Velpeau’s disease. It is a chronic disease and the boils don’t heal and often forms pus. Scarring may form later.
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Continuous appearance of lesions may lead to creation of connecting sinus tracts under the skin which connects the abscesses or lesions. The disease may be aggravated by emotional schanges, stress, hormonal changes, heat etc. The disease is not infections but is hereditary. It has been seen that people with HS often develop plugging of apocrine glands. Currently there is no specific treatment for the disease, but symptomatic treatment is done to provide relief. Incision and drainage of pus ameliorates the symptoms. Carbon dioxide laser surgery is an effective surgery. Antiseptics, sitz bath, hydrogen peroxide offers relief.
Hurley’s staging system- patients are classified into 3 groups depending on the symptomatology and extent of disease. Sartorius staging system – it is more sophisticated than the other system. Anatomic regions of the body affected by the disease, number and types of lesions, distance between lesions etc are used as indicators to classify the disease.
- Contractures and decreased mobility of lower limbs and axillae
- lymphedema of lower limbs
- Local and systemic infections like pneumonia, meningitis, bronchitis, sepsis.
- Interstitial keratitis
- Rectal or anal, urethral fistula
- Hypochromic or Normochromic anemia
- Squamous cell carcinoma
- Tumors of the lung and oral cavity
- Hypoproteinemia, amyloidosis, renal failure
- Seronegative arthropathy : polyarthritis/polyarthralgia, arthritis
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he Hidradenitis Suppurativa (Dermatology) pipeline guide also reviews of key players involved in therapeutic development for Hidradenitis Suppurativa and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Pre-Registration, Phase III, Phase II, Phase I, Preclinical and Unknown stages are 1, 2, 4, 1, 8 and 1 respectively.
Hidradenitis Suppurativa (Dermatology) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.
Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
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List of Figures
Number of Products under Development for Hidradenitis Suppurativa, H1 2017
Number of Products under Development by Companies, H1 2017
Number of Products by Targets, H1 2017
Number of Products by Stage and Targets, H1 2017
Number of Products by Mechanism of Actions, H1 2017
Number of Products by Stage and Mechanism of Actions, H1 2017
Number of Products by Routes of Administration, H1 2017
Number of Products by Stage and Routes of Administration, H1 2017
Number of Products by Molecule Types, H1 2017
Number of Products by Stage and Molecule Types, H1 2017
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