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TeloView Technology to Identify Presence and Severity of Alzheimer’s from Cheek Swab

March 29th, 2017 Conn Hastings Genetics, Geriatrics, Medicine, Neurology, Pathology, Psychiatry

3D Signatures, a company based in Manitoba, Canada, have developed the TeloView system, a software platform that can analyze telomere patterns in cells to diagnose disease. The company recently announced the results of a clinical study, due for publication in the Journal of Alzheimer’s Disease, in which the software could reportedly identify Alzheimer’s disease and predict if the disease was mild, moderate, or severe, based on analyzing a cheek swab sample from patients.

Telomeres are structures that protect the end of our chromosomes. 3D Signatures have researched the 3D arrangement of telomeres in healthy and diseased cells, with a view to developing diagnostic technologies. They have investigated telomere arrangements in a variety of cancers and in Alzheimer’s disease.

The study involved taking cheek swabs from 44 healthy volunteers and 44 patients with Alzheimer’s disease. The technology could distinguish between the healthy and Alzheimer’s samples and classify the disease severity of the of those with the affliction. A cheek swab is a non-invasive method to obtain a diagnosis. This is important, as currently Alzheimer’s disease can be difficult to diagnose specifically.

3D Signatures co-founder Dr. Sabine Mai, made the following statement, “Current diagnostic methods are not highly specific. In addition, Alzheimer’s disease is only confirmed postmortem pathologically. There is a significant need for an accurate, non-invasive biomarker that can diagnose Alzheimer’s disease and indicate disease progression, and we believe TeloView has the potential to answer that important call.”

See how the technology works below:

Link: 3D Signatures homepage…

Conn Hastings

Conn Hastings received a PhD from the Royal College of Surgeons in Ireland for his work in drug delivery, investigating the potential of injectable hydrogels to deliver cells, drugs and nanoparticles in the treatment of cancer and cardiovascular diseases. After achieving his PhD and completing a year of postdoctoral research, Conn pursued a career in academic publishing, before becoming a full-time science writer and editor, combining his experience within the biomedical sciences with his passion for written communication.

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