Enthesopathy is derived from a combination of entheso means a specific structure within the musculoskeletal system and pathy means presence of pathology. Enthesis was previously considered as the area where tendons in the body join the bone. But with the increasing research and pathological exploration, the term enthesis is now referred to as a disorder where ligaments, joint capsule and muscles join into the bone. The treatment of enthesis is complex as there are number of structures that are in close proximity to the enthesis. The enthesis organ is the most common target for attack in a number of systemic rheumatoid arthritis, more specifically the sero-negative spondyloarthropathies. Enthesopathy is encountered more in the sporting, fitness population or those who perform a repetitive task under load. While delivering an enthesopathy treatment it’s important to consider the presence of rheumatic diseases and other metabolic illnesses such as high cholesterol, diabetes and endocrine disorders.
The demand for enthesopathy treatment is expected to upsurge owing to the increasing number of sports injury, rising number of population going for workouts for good fitness score and the growing number of pathological research and increasing number of product pipeline by industry players. In around 4% of the population enthesopathy precede arthritis and is accompanied with morning heel pain and foot stiffness. Moreover, industry players are involved in expanding the product portfolio related to rheumatology. Janssen Biotech, Inc. presented more than 35 articles related to rheumatology portfolio at the American College of Rheumatology. The data included efficacy and safety data from Phase 3 studies of Stelara, Simponi Aria and Simponi.
ESWT is used for the treatment of calcific rotator cuff tendinopathy and plantar fasciitis. This treatment works by decreasing the conduction of signals along with fibers responsible for pain. Moreover, the shockwaves also stimulate the release of chemicals which stimulate the growth of blood vessels for healing process. Another recent but yet to be established technique is platelet rich plasma. In this technique the platelets are harvested in the individual’s blood and then injected in the area to be treated. The current research undertakings show promising results of healing process for enthesopathy and tendinopathy.
North America dominated the enthesopathy market owing to the industry participant research undertakings and government efforts towards arthritis treatment awareness. Ultragenyx Pharmaceutical, Inc. initiated a Phase 3 study for the treatment of pediatric patients with X-linked hypophosphatemia (XLH). XLH is a condition wherein there is inadequate mineralization of bones which leads to abnormalities such as enthesopathy, osteoarthritis and many more. Moreover, in the U.S. arthritis is not limited to older person but also prevalent in children. On the Juvenile Arthritis Awareness month there were 250 children diagnosed with juvenile arthritis. Asia Pacific is expected to be fastest growing region owing to the high incidence rate of arthritis thus posing a high enthesopathy treatment opportunity for international as well as domestic players. In India, obesity precede arthritis and hence the incidence rate of arthritis is high.
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Some of the enthesopathy treatment market contributors include Abbott Laboratories, Accuray Incorporated, Boston Scientific Corporation, C.R. Bard, Inc., Eli Lilly and Company, Janssen Biotech, Inc., Pfizer, Inc., Siemens AG, Varian Medical Systems, Inc., and Ultragenyx Pharmaceutical, Inc.
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