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Positive Animal Trial Results for Reversible Male Contraceptive

February 9th, 2017 Tom Peach Reproductive Medicine, Urology

VasalgelResearchers at the University of California have published positive results of a trial in rhesus monkeys for Vasalgel, a long-term, reversible, non-hormonal male contraceptive injection.

Vasalgel is injected in a similar manner to the no-scalpel vasectomy. In a vasectomy, the vas deferens, a small tube transporting sperm from the testes, is cut and results in sterilization. Vasalgel is instead injected into the lumen of the vas deferens where the gel forms a blockage that does not allow sperm to penetrate. The temporary reduction in sperm count can then be reversed after months or years with a separate injection that dissolves the polymer plug, returning the vas deferens to full functionality.

Published in the Journal of Basic and Clinical Andrology, the study showed that of the 16 adult male rhesus monkeys injected with Vasalgel none fathered offspring in a two-year period of mating. No major side effects were reported and any procedural complications were considered to be similar to those associated with traditional vasectomy. The study did not investigate the success of reversing the procedure after two years. However, this trial in monkeys follows previous positive results of Vasalgel use in rabbits, where the reversal of the procedure was shown to be successful immediately following a 12-month period of sterilization.

The development of Vasalgel has been conducted by the Parsemus Foundation, a non-profit based in Berkley, CA, that utilizes grants and fundraising to advance innovative but neglected medical research. The foundation hopes to begin a trial of Vasalgel in humans in the next two years.

Info page: Vasalgel…

(image: Parsemus Foundation…)

Tom Peach

Tom is a Biomedical Engineering researcher currently based at University College London. He holds a DPhil (PhD) in Biomedical Engineering from the University of Oxford, and both Bachelors and Masters degrees in Engineering from the University of Cambridge. Tom's current research focuses on medical device development and modeling, particularly in the cardiovascular and cerebral spaces. He consults for a number of medical device spinouts, and has a passion for research and the medical device industry--from basic science to start-ups and commercialization.

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