The protein labeling market can be segmented based on product type, labeling method, end-user, and region. In terms of product type, the market can be segmented into instruments, kits and reagents, and services. The instruments segment comprises fluorescence microscopy, protein microarrays, and mass spectrometry. Reagents can be further segmented into enzymes, monoclonal antibodies, probes or tags, proteins, and other reagents.
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Based on labeling method, the protein labeling market can be segmented into in vivo labeling and in vitro labeling. In vivo labeling or metabolic labeling is a method to label all proteins or nucleic acids in a cell by culturing them with amino acids or nucleotides, respectively. In vivo labeling is further segmented into radioactive labeling and photo-reactive labeling. In vitro labeling involves chemical method of protein labeling by covalent attachment of label to amino acids using label conjugates to chemical group that react with specific amino acids. In vitro labeling is further segmented into nanoparticle labeling, dye-based labeling, enzymatic labeling, and site-specific labeling. In vitro labeling is expected to be the fastest growing segment during the forecast period.
In terms of end-user, the protein labeling market can be categorized into pharmaceutical & biotechnology companies, contract research organizations, and academic and research institutes. Pharmaceutical and biotechnology companies is expected to be the fastest growing segment due to increasing R&D spending in pharmaceutical and biotechnology sector globally.
Geographically, the protein labeling market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America and Europe are likely to dominate the protein labeling market. Rising number of proteomics research studies in the region is the key driver of the protein labeling market in North America and Europe. Asia Pacific is expected to be the most progressive market for protein labeling. Increasing health care spending and growing medical tourism are projected to drive the market in Asia Pacific. Rising adoption of personalized medicine therapy is another factor propelling the market in the region. Increasing research and development expenditure and health care expenditure by government is likely to contribute to the growth of the market. However, lack of skilled professionals and high degree of market consolidation could negatively impact the growth of the market during the forecast period.
Labeling of specific protein or protein of interest by chemical and/or other biological material for detection, identification, and activity determination, and to identify its physicochemical properties is known as protein labeling. Chemical labels such as fluorescent dyes, biotin, radioactive isotope, and enzymes are used for labeling of proteins. These help generate a detection signal, which are increasingly utilized in key biotechnology applications. The labeled secondary antibodies are readily available in the market, but unique and more specific probes are witnessing increasing demand in research applications. These labels can be conjugated to antibodies and other specific probes using various crosslinking technologies.
Three types of tags are utilized in protein labeling processes: mass tags, stable isotopes, and fluorophores. Mass spectrometry is utilized for labeling and separation of mass tags and stable isotopes, while fluorescence imagers are used for detection of fluorescence labels. Protein labeling is becoming essential for proteomic profiling prior to separation and analysis of proteins or amino acids. However, the main purpose of protein labeling is specific detection and quantification of isomers, protein modifications in multiplexed samples, and monitoring of biological processes. Protein labeling enhanced the detection sensitivity as well as simplifies the detection workflow. Proteins can be labeled in biological fluids during cell growth by incorporation of amino acids containing isotopes, tissue samples by attaching specific group or other residues.
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Major players operating in the protein labeling market are Thermo Fisher Scientific, Inc., Merck KGaA, F. Hoffmann-La Roche Ltd., Promega Corporation, SeraCare Life Sciences, Inc., and LI-COR, Inc.
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