Lambert-Eaton Myasthenic Syndrome (LEMS) exceptional autoimmune syndrome involving improper transmission at neuromuscular junction with the key clinical symptom of muscle weakness. Weakness in muscles in LEMS is caused due to autoantibodies to voltage gated calcium channels resulting in reduction of acetylcholine released from terminals of the nerve. The necessary knowledge of elusive clinical features and laboratory oddities makes the early identification of LEMS possible. Early detection of LEMS is principally significant due to its strong correlation with small cell lung cancer (SCLC). Even though LEMS can arise at any point in the path of SCLC, it serves as a marker for early detection of the disease, and thus permits better opportunity for treatment of such malignancy. Patients with LEMS should be examined and then treated by both a neurologist and if appropriate, an oncologist. In case of the diagnosis the principal concern must be appropriate treatment of malignancy. Treatment of LEMS includes immunosuppressant agents, but success of the treatment depends on toxicity and trouble involved in administering the therapy.
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Treatment of LEMS involves various approaches that include reducing the amount of antibodies so as to improve the muscle function, increasing the acetylcholine quantity received by the muscles, increasing the overall acetylcholine released in the body and other mechanism which are not approved in all the regions. The therapy involving reduction in the amount of antibodies comprises of corticosteroids, cyclosporine, azathioprine, monoclonal antibodies and many more. The therapy involving the amount of acetylcholine reception by the muscles comprises of Cholinesterase inhibitors. The therapy involving the increased amount of acetylcholine production in the body comprises of aminopyridines. There is a drug which treats the disorder but those are not approved in all the regions. This category includes amifampridine which is approved only in European countries.
The Global Lambert Eaton Myasthenic Syndrome (LEMS) Therapeutics market can be segmented by Treatment type, Disease Type, Distribution Channel and Region.
Geographically, the North America are anticipated to be most lucrative market during the forecast period, mainly owing to high prevalence of the disease and better reimbursement policies. Moreover the existence of several drug manufacturers and growing amount of clinical research is anticipated to promote rapid market growth in this region. Asia Pacific region is anticipated to observe high market development followed by North America and Europe mostly owing to patient population and better and affordable therapy options by the companies operating in this market. The large patient pool and refining distribution channel in the region is also likely to lift the LEMS market. Latin America and Middle East and Africa are anticipated to follow owing to growing government expenditure on the healthcare.
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Some of the major players in the global LEMS therapeutic market are Catalyst Pharmaceuticals, Inc., GlaxoSmithKline plc, Merck & Co., Inc., Sanofi S.A., Allergan, Plc, Novartis International AG, F. Hoffmann-La Roche AG, Biomarin Pharmaceutical Inc.
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