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DNA Computer Can Sense Multiple Antibody Inputs, With Potential for Smart Drug Delivery

February 21st, 2017 Conn Hastings Genetics, Medicine, Nanomedicine, Oncology, Pathology

Researchers at the University of Eindhoven in the Netherlands have developed a DNA computer that can respond to the presence of specific antibodies and make calculations, with the potential for intelligent drug delivery in the future. DNA computing involves using DNA molecules and other molecular biological components as molecular circuitry, instead of traditional silicon-based circuitry in computer devices. The DNA sequence dictates which other DNA molecules a DNA strand can interact with, allowing researchers to program DNA circuitry.

Scientists have been trying to use DNA computing as a method to detect biomarkers of disease in the body. Using this technique, a DNA computer could make calculations and perform a specific function, such as release a drug or activate an enzyme, in response to biological stimuli such as disease biomarkers.

So far, the inputs of DNA computers have been other DNA or RNA molecules, which has limited their usefulness as diagnostic or therapeutic systems. However, in this study, published in Nature Communications, scientists have developed a DNA computer that can respond to multiple antibody inputs and perform calculations to formulate an appropriate response. Antibodies are biomarkers in a variety of diseases, meaning that the new system has significant potential as an intelligent drug delivery system. The system translates the presence of an antibody into a DNA strand, that can then interact with other DNA strands in the molecular circuitry in calculating the appropriate response.

First author on the study, Wouter Engelen, explained how the system works once an antibody has caused the computer to produce a specific DNA strand: “The presence of a particular DNA molecule sets in motion a series of reactions whereby we can get the DNA computer to run various programs. Our results show that we can use the DNA computer to control the activity of enzymes, but we think it should also be possible to control the activity of a therapeutic antibody.”

Study in Nature Communications: Antibody-controlled actuation of DNA-based molecular circuits…

Via: Eindhoven University of Technology…

Image: ICMS Animation Studio

Conn Hastings

Conn Hastings received a PhD from the Royal College of Surgeons in Ireland for his work in drug delivery, investigating the potential of injectable hydrogels to deliver cells, drugs and nanoparticles in the treatment of cancer and cardiovascular diseases. After achieving his PhD and completing a year of postdoctoral research, Conn pursued a career in academic publishing, before becoming a full-time science writer and editor, combining his experience within the biomedical sciences with his passion for written communication.

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