Parenteral formulations are sterile liquid or solid dosages (powder) packaged in either single or multi dose containers. Intended for administration by injection or infusion, parenteral preparations provide maximum bioavailability and efficacy than the oral dosage forms. Largely, parenteral preparations are classified based on their volume into small and large volume parenteral formulations. Small volume parenteral preparations are 100 ml or less and can be prepared as single dose or multiple dose product. On the other hand, large volume parenteral (LVP) preparations are more than 100 ml solutions intended to be used as single dose intravenous infusions. Commonly used large volume parenteral formulations include intravenous infusions of amino acid, dextrose, mannitol, ringer’s injection, lactated ringer injection and sodium chloride injection.
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The therapeutic goal of IV infusion is to provide electrolytes, body fluids and nutrition as a part of maintenance and replacement therapy. Based on this understanding, the large volume parenteral market is analyzed through three categories namely, injections for fluid balance, therapeutic injections and nutritious injections. Fluid balance injection administer electrolytes to traumatic patients and those in need of electrolytes such as potassium, sodium and chloride. Therapeutic injections widely cater to vaccines, anti-infective, oncology, diabetes and gastrointestinal drug administration. Intake of nutrition by unconscious and unhealthy patients is essential for recovery and hence they are administered effectively through IV infusion.
Increasing rate of hospitalization and surgeries is one of the essential driving factors for LVP preparations. Also, rise in demand for more effective, faster and safer drug administration in patients undergoing surgeries will drive the demand for large volume parenteral preparations. The advent for single dosage in diabetes, oncology, vaccines and central nervous system disorders will further fuel the market for large volume parenteral preparations.
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Some of the key players in this market include Kelun Pharma, Otsuka Pharmaceutical, Patheon Inc., Wockhardt Ltd., Teva Pharmaceutical Industries Limited, Baxter Healthcare Corporation, BAG Healthcare GmbH, Cook Pharmica LLC, Hospira, Inc. and Southwest Pharmaceutical Co. Ltd.
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