Tissue engineered skin substitutes or artificial skin substitutes can be defined as bioengineered skin substitutes derived from human tissue, non-human tissue, synthetic materials, and composite of the above materials. Tissue engineered skin substitutes are made up of cells, the extracellular matrix, and combination of cells and matrices. These are mostly used for the treatment of burns, diabetic ulcers, vascular ulcers, and lacerations. Biological skin substitute is recognized as an ultimate standard for the treatment of burn, diabetic ulcer and vascular ulcers as it is easy-to-use, safe, and provides effective/permanent treatment in a short time span. In addition, rapidly increasing diabetic patients and vascular ulcer cases are likely to boost the global demand for tissue engineered skin substitutes. Rising sports injuries and rapidly growing obese population boosts demand for tissue engineered skin substitutes globally. However, lack of favorable reimbursement policies pertaining to the treatment of vascular disease and high risk of post-implementation infection associated with allogeneic skin substitutes is expected to restrict market growth. The global tissue engineered skin substitutes market was valued at USD 958.8 million in 2014 and is projected to reach USD 3,873.5 million by 2023, expanding at a CAGR of 17.2% from 2015 to 2023.
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Based on type, the global tissue engineered skin substitutes market has been segmented into acellular, cellular allogeneic, cellular autologous, and others. The acellular skin substitute segment accounted for the largest share and is anticipated to expand at the highest CAGR during the forecast period from 2015 to 2023. The dominance of this segment was primarily due to low cost, easy availability, and high demand for the products. Moreover, effective treatment result and growing preference for innovative and comfortable skin substitutes are the other factors supporting market growth.
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Based on application, the global tissue engineered skin substitutes market has been segmented into burn Injury, diabetic ulcer/vascular ulcer, and others. The diabetic ulcer application segment accounted for the largest share in 2014. This is primarily due to high prevalence of diabetic ulcers and growing demand for biological skin substitutes for diabetic ulcer treatment. For instance, according to International Diabetes Federation (2014), around 387.0 million people are suffering from diabetes, of these around 25.0% of the patients are diagnosed with diabetic ulceration which require extensive healing time. Skin substitutes are the ultimate choice for patients suffering from acute diabetic ulcers. Hence, escalating number of diabetic patients is likely to fuel the growth of tissue engineered skin substitutes market. The diabetic ulcer application segment is anticipated to expand at the highest growth rate during the study period.
Geographically, North America was the largest market for tissue engineered skin substitutes in 2014. Increasing prevalence of vascular ulcers and rising demand for various advanced tissue engineered skin products propel the growth of the market in the region. For instance, the Centers for Disease Control and Prevention published a report in March 2015 which stated that approximately 900,000 people are affected by deep vein thrombosis (DVT) in the U.S. each year. Hence, rise in DVT cases is likely to boost demand for tissue engineered skin substitutes in North America.
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The tissue engineered skin substitutes market in Asia Pacific is anticipated to witness the fastest growth rate during the forecast period as compared to North America and Europe. Increasing geriatric population in countries such as Japan, China, and Singapore have increased demand for accurate and reliable biological skin products, thereby driving the market in the region. Moreover, rising disposable income and increase in health care infrastructure in countries such as India, China, and Malaysia would support market growth.
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