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Collabody System for The Delivery of Anticancer Drugs

November 14th, 2016 Conn Hastings Oncology

collabody-sideThe Industrial Technology Research Institute (ITRI), based in Taiwan, has developed the Collabody drug delivery platform, a molecular therapy to enhance and supplement anti-cancer protein drugs. Currently, many anticancer drugs demonstrate poor specificity for cancer cells, meaning that they negatively affect many non-cancerous cells in the body, leading to dose-limitation and off-target effects. The Collabody system enhances the crosslinking activity of anticancer protein drugs with target molecules on the surface of cancer cells, helping to increase protein drug specificity and reduce the interaction of the drug with non-cancerous cells.

The Collabody system consists of a collagen-peptide scaffold that supports multiple target-binding sites, engineered using antibody fragment fusion technology. Tailored for the delivery of anti-cancer protein drugs, this system can bind to multiple target sites on cancer cells. Not only does it bind to cancer cells, but it also targets molecules involved in the immune system. This can result in recruitment and activation of T-cells, which contribute to killing cancer cells at the tumor site.

collabody

The system is currently in animal testing and has shown promise, particularly in animal models of lung cancer. The vice president and general director of Biomedical Technology and Device Research Laboratories of ITRI, Yio-Wha Shau said in a statement:

“If clinical trials on a larger scale are approved, the drug delivery platform is expected to have applications in colon cancer, and head and neck cancers, among others. It is hoped that Collabody will be more effective in treating cancers than current approaches, enabling protein drugs to gradually become more commonly produced by the pharmaceutical community.”

The Collabody concept is illustrated in the following video:

Info page: Collabody…

Conn Hastings

Conn Hastings received a PhD from the Royal College of Surgeons in Ireland for his work in drug delivery, investigating the potential of injectable hydrogels to deliver cells, drugs and nanoparticles in the treatment of cancer and cardiovascular diseases. After achieving his PhD and completing a year of postdoctoral research, Conn pursued a career in academic publishing, before becoming a full-time science writer and editor, combining his experience within the biomedical sciences with his passion for written communication.

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