Malignant glioma’s are one of the common sub-type of primary brain tumors which are highly invasive, aggressive and neurologically destructive tumors among the deadliest human cancers. Gliomas account for around 45% of primary brain tumors where children are less likely to develop the risk of gliomas. Gliomas arise from the glial cells or non-neuronal cells hence the name and the cells are supposed to provide support and protection for neurons in the central nervous system and peripheral nervous system. Gliomas are caused due to growing or invading into or creating pressure in nearby the normal brain tissues developing tumors in the brain and spinal cord. According to the grading by WHO (World Health Organization), the grade III tumors are malignant and lead to death within 12 to 24 months. Currently more than 60% of the clinical trials in gene therapy are focused on targeting cancer.
Cancer is one of the major and global health issue faced accounting for approximately 8 million deaths globally. Heredity, geography, exposure to electromagnetic radiation and gender are some factors responsible for most of the gliomas. There is no such population or geographies where the risks for malignant glioblastoma is less hence the treatment area is much wide and has large scope for future advancements. The factors which affect this market include the limitations of chemotherapy, approvals rate for various drugs and therapies by regulatory bodies and increasing population. Lifestyle changes is one of the leading factor to acceleration of this market and indulge companies to select promising novel treatments entering the clinical arena.