Biosimulation refers to a process involving simulation of biological processes with the help of computer sided mathematical models. Biosimulation is an integral part of systems biology and helps in clinical drug development, drug metabolism and modeling of complex biomedical systems. Need for reduction in the cost of drug discovery and development and risk of failure of drug molecule in the late phase are some of the main factors which help to drive the market. On the basis of application, biosimulation market can be segmented into drug discovery and drug development. Drug discovery includes target identification, target validation, lead identification and lead optimization.
Target identification includes protein structure prediction, target validation includes protein modeling software, lead identification includes de novo design and lead optimization includes quantitative structure-activity relationship (QSAR) models. Drug development includes pre-clinical testing, clinical trials and in-patient validation. Pre-clinical testing includes ADME/tox prediction, pharmacokinetic/pharmacodynamic (PK/PD) models and clinical trials includes phase I clinical trial, phase II clinical trial and phase III clinical trial.
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