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Riverain ClearRead CT Suppresses Vessels and Detects Nodules on Chest CT

September 29th, 2016 Wouter Stomp Radiology

riverain-clearread
Riverain Technologies‘ new ClearRead CT software for vessel suppression and nodule detection has been cleared by the FDA. While previous Riverain products all worked on conventional chest X-rays (and have since been rebranded ClearRead X-Ray), the company is now breaking new ground by applying advanced machine learning algorithms on lung CTs. ClearRead CT consists of two components: CT | Vessel Suppress and ClearRead CT | Detect.

ClearRead CT Vessel | Suppress uses machine learning and advanced modelling to suppress vascular structures as well as the bronchial tree and pulmonary fissures; essentially all normal structures, leaving only nodules in sight. The vessel suppression algorithm works with both contrast and non-contrast scans, and with both solid and non-solid nodules, including pure ground-glass nodules. It was designed to operate for nodules that are roughly spherical and at least 3mm in diameter. In a clinical study including thousands of actual nodules none of the nodules were removed, although as a consequence of a conservative approach there were some false positives. Therefore positive results are to be checked against the original scan to confirm the presence of a true nodule.

ClearRead CT | Detect takes this technology one step further, working on top of the vessel suppression component, detecting candidate nodules 5mm or larger using thresholding and morphological post-processing. Detected nodules are segmented and characterized, providing density, minimal and maximal diameters, and nodule volume. Consistent with vessel suppression some false positives are expected.

In a multi-reader, multi-case clinical trial ClearRead CT helped radiologists achieve a 29% reduction in missed actionable nodules, while reducing reading time by 26%. The software is compatible with all CT scanners from all vendors and is available for sale in the United States, Canada, and Europe.

Press release: FDA clears way for ClearRead CT Software…

Product page: Riverain ClearRead CT…

Wouter Stomp

Wouter Stomp is a radiology resident at the radiology department of Leiden University Medical Center, the Netherlands. He is also a PhD candidate with his research focussing on the role of MRI in early rheumatoid arthritis.

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