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Novel Dual-Sided Pill Shows Promise as a Slow-Release Drug Strategy

April 8th, 2016 Iris Kulbatski News

double-pillA new pill designed to attach to the gastrointestinal lining and release its contents slowly has been developed by researchers from MIT and Brigham and Women’s Hospital. Engineered according to the principles of a Janus device, the new pill has two distinct sides: a mucoadhesive side and an omniphobic side. The former adheres to mucosal surfaces, while the latter repels liquids and food, thereby resisting detachment from the gastrointestinal mucosa. Carbopol, a polymer used commercially as a stabilizer/thickener, comprises the mucoadhesive side of the pill, whereas microtextured fluorinated cellulose acetate comprises the omniphobic side. Drugs can be incorporated into the cellulose acetate itself or embedded between the two layers of the pill.

Although the use of mucoadhesives has been previously explored as a strategy for slow-release drugs in the gastrointestinal system, this novel dual-sided pill is unique in that it prevents liquid and food in the stomach from sticking to the pill and drawing it away from the mucosal lining before the drug is fully released.  Frequently dosed drugs, such as antibiotics, are ideal candidates for extended-release, which may reduce the frequency of dosing, thereby improving patient compliance.

To date, the researchers have demonstrated proof of principle in an ex vivo model, with additional in vivo studies planned in the near future.

Study in Advanced Healthcare Materials: A Janus Mucoadhesive and Omniphobic Device for Gastrointestinal Retention

Original report: MIT

 

Iris Kulbatski

Iris Kulbatski (PhD Medical Science, University of Toronto) is a Research Associate and Science Writer, with broad subject matter expertise, including medical devices, stem cell biology, regenerative medicine, cell/tissue bioengineering, cell transplantation, neuroscience, brain and spinal cord injury, spinal cord regeneration, and medical imaging. She has over a dozen peer-reviewed publications, including original research articles, a book chapter, and several review articles. As a biomedical writer and editor for medical device companies, physicians, and scientists, she has developed, written and edited marketing material, technical protocols, educational material, white papers, press releases, promotional material, presentations, web and newsletter content, editorials, e-blasts, manuscripts, abstracts, book chapters, and grant proposals.

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