Liposomes have been studied extensively as vehicles for targeted delivery of drugs throughout the body because of their beneficial characteristics, but they’re still recognized by the immune system. That means that there could be a host of unexpected reactions to liposome-based treatments. Now researchers at the University of Basel and University of Fribourg in Switzerland have created artificial phospholipid vesicles that are seemingly ignored by the immune system.
The new vesicles were tested within the blood serum of both pigs and humans and have caused no immune response whatsoever. The researchers also injected three pigs with the new liposomes and monitored the pigs, including their ECG and blood pressure. The researchers delivered large quantities of the liposomes, attempting to force a reaction, but there seemed to not have been one of any importance.
Study in journal Nanomedicine: Surprising lack of liposome-induced complement activation by artificial 1,3-diamidophospholipids in vitro…