An international team of researchers has developed new fluorescent probes able to detect specific biomarkers within cells. The technology may allow for early detection of cancer, monitoring the activity of drugs, and for studying intracellular processes. The probes consist of a peptide that sticks to target molecules and a novel fluorescent tag that can be tracked under a microscope.
Because these new combination particles are much more sensitive than similar previously developed devices, they should be able to provide concentration measurements that are indicative of the extent of disease, the penetration of drugs inside of cells, and other biological processes. The researchers also believe the technique may improve the usefulness of PET scans.
Study in Nature Communications: Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue…
Source: University of Edinburgh…