Digital microscopy has been a major player in improving scientific research, and it is changing how clinical pathology labs are run. The technique, which relies on sensors full of pixels, has its downsides and in certain cases produces less than ideal pictures. Now researchers at California NanoSystems Institute at University of California, Los Angeles have developed a technique called “pixel super-resolution using wavelength scanning” that can result in much sharper images.
The technique scans the sample under the microscope repeatedly using different wavelengths of light. Using this information, a special algorithm combines the scans into one in which individual pixels are smaller than the original.
The researchers tested the microscopy technique on blood samples and pap smears, demonstrating high resolution imaging, both on stained and unstained samples.
Study in Light: Science and Applications: Pixel super-resolution using wavelength scanning…
Source: UCLA…