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Nature Inspired Approach Towards DNA Origami Allows for Complex Nanobots

March 31st, 2015 Joshua Chen Nanomedicine, News

dna-origami-glueResearchers at the Technische Universität München (TUM) developed a new tool in the ever expanding field of DNA origami. TUM Professor Henrik Dietz and his lab have developed a new way to “glue” DNA nanostructures together. Until now, DNA nanostructures have been created using the idea of “base-pairings,” in which nucleotides come together with their complementary nucleotides to form an almost unbreakable bond, and thus folding DNA strands into specific shapes. However, with this approach, you can’t design very complex dynamic structures. Now, the TUM group has taken inspiration from the natural process of combining complementary shapes of RNAse and transfer RNA. They designed the folded pieces of DNA so that it would have complementary geometries that could then be “snapped” into place. By altering the interaction strengths between the DNA building blocks, Dietz and his lab have allowed for a greater flexibility when designing 3D DNA nanostructures such as switchable gears, a tiny “book” that opens and closes, and even an actuator.

nanorobotIn fact, the researchers have used transmission electron micrographs to image a three-dimensional humanoid nanorobot to confirm that their technique had worked in putting the pieces together. Furthermore, with this new technique, adjusting the temperature can actually change the configurations of the nanostructures without any degradation. Previously, raising and lowering the temperature would cause separating and re-joining of base pairs which would ultimately wear out the system.

TUM Press Release: Designer’s Toolkit for Dynamic DNA Nanomachines

Study in Science: Dynamic DNA Devices and Assemblies Formed by Shape-Complementary, Non-Base Pairing 3D Components

Joshua Chen

A student at University of California, Berkeley studying bioengineering, Josh Chen is an avid researcher passionate about 3D printing, stem cells, neuroscience, biomaterials, nanotechnology and so much more. He hopes to take aspects in engineering and combine it with medicine to improve the quality of lives of others by creating low cost solutions to solve large-scale medical problems in the future. As Josh closely follows new therapies and technologies, he is inspired by the monumental work that scientists do each and every day. Josh has worked on various projects including a miRNA cancer research, high-throughput drug screening tests for Parkinson's disease, and currently working on substrate cellular interactions.

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