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Advancements In Gold Nanotechnology for Fighting Cancer

February 17th, 2015 Joshua Chen News

gold-nanotubesA study published in the scientific journal Advanced Functional Materials describes for the first time the treatment of  a human cancer in a mouse model using gold nanotubes. The group is able to control the length and tunable absorption of these gold nanoparticles in the near-infrared (NIR) region using a length-controlled synthesis method. They then apply a coating of poly(sodium 4-styrenesulfonate) (PSS) to allow the nanoparticles to maintain colloidal properties while maintaining low cytotoxicity.

The study was led by Dr. Sunjie Ye from the University of Leeds’ School of Physics and Astronomy, and also the Leeds Institute for Biomedical Sciences and Clinical Sciences. She and her team demonstrated potential applicability for treating cancer with photothermal ablation and using these gold nanotubes as a contrast agent for a new type of  imaging technique called ‘multispectral optoacoustic tomography’ (MSOT). By using a pulsed laser beam, the scientists were able to raise the temperature of the nanoparticles very quickly, high enough to destroy cancer cells. Furthermore, they were also able to adjust the brightness of the laser pulse so that the nanoparticles could be used as a contrast agent.

The nanotubes were injected intravenously into the mouse model, and the particles were observed to be excreted. In the future, the nanotubes could be tumor targeting and the hollow core could be used to hold therapeutic agents, which would pave the way towards greater personalized medicine with low toxicity levels.

The University of Leeds: Gold Nanotubes Lauch a Three-Pronged Attack on Cancer Cells

Study in Advanced Functional Materials: Engineering Gold Nanotubes with Controlled Length and Near-Infrared Absorption for Theranostic Applications

Joshua Chen

A student at University of California, Berkeley studying bioengineering, Josh Chen is an avid researcher passionate about 3D printing, stem cells, neuroscience, biomaterials, nanotechnology and so much more. He hopes to take aspects in engineering and combine it with medicine to improve the quality of lives of others by creating low cost solutions to solve large-scale medical problems in the future. As Josh closely follows new therapies and technologies, he is inspired by the monumental work that scientists do each and every day. Josh has worked on various projects including a miRNA cancer research, high-throughput drug screening tests for Parkinson's disease, and currently working on substrate cellular interactions.

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