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Self-Powered Rocket Nanovesicles to Ferry Drugs Around Body Able to Open and Close Using External Magnets

September 25th, 2014 Medgadget Editors Nanomedicine

rocket-mini

rocket-nanoparticles

Electron microscope images of the vesicles. Without a magnetic field (0 Tesla, left), the vesicles have a small opening. In a strong magnetic field (Tesla 20, right), they are deformed by the magnetic alignment, resulting in a large opening of the vesicle.

We’ve written about a bunch of different drug ferrying nanoparticles that scientists around the world have been developing. The more interesting ones tend to have unique sets of abilities that together overcome a number of obstacles. Researchers at Radboud University in The Netherlands have just reported on a new method of manipulating polymersomes to be able to hold onto drugs while providing their own rocket-like propulsion inside the body.

Because polymersomes consist of diamagnetic block-copolymers, the researchers were able to manipulate them with magnets to take on a shape of a ball with one outside point pushed into its center. Having this structure allows large compounds to be placed inside. Nevertheless, a small opening remains, which, while keeping a drug or other substance within, can be used as a exhaust port. Smaller molecules are placed inside the vesicle that are made to react with each other, producing pressure that pushes everything but the larger cargo outward. Like a rocket, the nanovesicle can move forward and once it reaches its destination, a magnet can be used to open up the so called “magneto-valves” and release the larger cargo.

Here’s a quick and cute video explaining the technology:

 

Article in Nature Communications: Polymersome magneto-valves for reversible capture and release of nanoparticles…

Press release: Magnetic field opens and closes nanovesicle…

Medgadget Editors

Medical technologies transform the world! Join us and see the progress in real time. At Medgadget, we report the latest technology news, interview leaders in the field, and file dispatches from medical events around the world since 2004.

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