Electron microscope images of the vesicles. Without a magnetic field (0 Tesla, left), the vesicles have a small opening. In a strong magnetic field (Tesla 20, right), they are deformed by the magnetic alignment, resulting in a large opening of the vesicle.
We’ve written about a bunch of different drug ferrying nanoparticles that scientists around the world have been developing. The more interesting ones tend to have unique sets of abilities that together overcome a number of obstacles. Researchers at Radboud University in The Netherlands have just reported on a new method of manipulating polymersomes to be able to hold onto drugs while providing their own rocket-like propulsion inside the body.
Because polymersomes consist of diamagnetic block-copolymers, the researchers were able to manipulate them with magnets to take on a shape of a ball with one outside point pushed into its center. Having this structure allows large compounds to be placed inside. Nevertheless, a small opening remains, which, while keeping a drug or other substance within, can be used as a exhaust port. Smaller molecules are placed inside the vesicle that are made to react with each other, producing pressure that pushes everything but the larger cargo outward. Like a rocket, the nanovesicle can move forward and once it reaches its destination, a magnet can be used to open up the so called “magneto-valves” and release the larger cargo.
Here’s a quick and cute video explaining the technology:
Article in Nature Communications: Polymersome magneto-valves for reversible capture and release of nanoparticles…
Press release: Magnetic field opens and closes nanovesicle…
