• Popular
    • Medicine
    • Radiology
    • Cardiology
    • Surgery
    • Nanomedicine
    • Military Medicine
    • Rehab
  • Categories
    • Exclusive
    • A-D
      • Anesthesiology
      • Art
      • Cardiac Surgery
      • Cardiology
      • Critical Care
      • Dentistry
      • Dermatology
      • Diagnostics
    • E-I
      • Emergency Medicine
      • ENT
      • Genetics
      • Geriatrics
      • GI
      • Informatics
    • M-N
      • Medicine
      • Military Medicine
      • Nanomedicine
      • Net News
      • Neurology
      • Neurosurgery
      • Nuclear Medicine
    • O-P
      • Ob/Gyn
      • Oncology
      • Ophthalmology
      • Orthopedic Surgery
      • Pathology
      • Pediatrics
      • Plastic Surgery
      • Psychiatry
      • Public Health
    • R-V
      • Radiation Oncology
      • Radiology
      • Rehab
      • Reproductive Medicine
      • Space Medicine
      • Sports Medicine
      • Surgery
      • Thoracic Surgery
      • Urology
      • Vascular Surgery
  • SUBSCRIBE
  • Submit PR
  • About
  • Follow
    • Facebook
    • Twitter
    • Linkedin
    • Youtube
    • Instagram
    • RSS
  • Submit PR
  • Log in
Medgadget
Medgadget
  • Popular
    • Medicine
      Magnetic Dressing Improves Diabetic Wound Healing

      Magnetic Dressing Improves Diabetic Wound Healing

      Eko’s Newest CORE 500 Stethoscope: A Review

      Eko’s Newest CORE 500 Stethoscope: A Review

      Microfluidic System Incorporates Eight Organ Tissues for Drug Testing

      Microfluidic System Incorporates Eight Organ Tissues for Drug Testing

      Suction Cup Delivers Drugs Through Cheek

      Suction Cup Delivers Drugs Through Cheek

    • Radiology
      Shear-Thinning Biomaterial for Embolic Applications: Interview with Upma Sharma, President and CEO of Arsenal Medical

      Shear-Thinning Biomaterial for Embolic Applications: Interview with Upma Sharma, President and CEO of Arsenal Medical

      Ultrasound-Equipped Bra Monitors for Breast Cancer

      Ultrasound-Equipped Bra Monitors for Breast Cancer

      Portable and Radiation-Free Imaging with Magnetic Nanoparticles

      Portable and Radiation-Free Imaging with Magnetic Nanoparticles

      Imaging Technique Reveals Living Brain Tissue in its Complexity

      Imaging Technique Reveals Living Brain Tissue in its Complexity

    • Cardiology
      Eko’s Newest CORE 500 Stethoscope: A Review

      Eko’s Newest CORE 500 Stethoscope: A Review

      Shear-Thinning Biomaterial for Embolic Applications: Interview with Upma Sharma, President and CEO of Arsenal Medical

      Shear-Thinning Biomaterial for Embolic Applications: Interview with Upma Sharma, President and CEO of Arsenal Medical

      Ultrasound-Equipped Bra Monitors for Breast Cancer

      Ultrasound-Equipped Bra Monitors for Breast Cancer

      3D Printed Heart Muscle Beats

      3D Printed Heart Muscle Beats

    • Surgery
      Magnetic Dressing Improves Diabetic Wound Healing

      Magnetic Dressing Improves Diabetic Wound Healing

      Sensor Monitors Transplanted Organs for Signs of Rejection

      Sensor Monitors Transplanted Organs for Signs of Rejection

      Refillable Device for Drug Delivery Past the Blood-Brain Barrier: Interview with Mike Maglin, CEO at CraniUS

      Refillable Device for Drug Delivery Past the Blood-Brain Barrier: Interview with Mike Maglin, CEO at CraniUS

      Droplet Battery Harnesses Ionic Gradients for Bioelectronic Implants

      Droplet Battery Harnesses Ionic Gradients for Bioelectronic Implants

    • Nanomedicine
      Nanorobots Release Reactive Oxygen Species to Kill Fungal Biofilms

      Nanorobots Release Reactive Oxygen Species to Kill Fungal Biofilms

      Bottlebrush Nanoparticles Deliver Immunostimulatory Drugs

      Bottlebrush Nanoparticles Deliver Immunostimulatory Drugs

      Nanoparticles Deliver mRNA Therapy to the Lungs

      Nanoparticles Deliver mRNA Therapy to the Lungs

      Nanoparticles Get Lymphatic Vessels Pumping

      Nanoparticles Get Lymphatic Vessels Pumping

    • Military Medicine
      Wearable Can Take Multiple Sweat Samples

      Wearable Can Take Multiple Sweat Samples

      Wound Dressing Detects Infection, Changes Color

      Wound Dressing Detects Infection, Changes Color

      Device Measures Hemoglobin More Accurately in Dark Skin

      Device Measures Hemoglobin More Accurately in Dark Skin

      Fingertip Sensor Measures Lithium Levels in Sweat

      Fingertip Sensor Measures Lithium Levels in Sweat

    • Rehab
      Stretchable E-Skin for Robotic Prostheses

      Stretchable E-Skin for Robotic Prostheses

      Glasses Provide Audible Prompts for Blind Wearers

      Glasses Provide Audible Prompts for Blind Wearers

      A Wearable to Manage Parkinson’s Motor Symptoms: Interview with Lucy Jung, CEO at Charco Neurotech

      A Wearable to Manage Parkinson’s Motor Symptoms: Interview with Lucy Jung, CEO at Charco Neurotech

      Robotic Ankle Helps with Postural Control in Amputees

      Robotic Ankle Helps with Postural Control in Amputees

  • Categories
    • Exclusive
    • A-D
      • Anesthesiology
      • Art
      • Cardiac Surgery
      • Cardiology
      • Critical Care
      • Dentistry
      • Dermatology
      • Diagnostics
    • E-I
      • Emergency Medicine
      • ENT
      • Genetics
      • Geriatrics
      • GI
      • Informatics
    • M-N
      • Medicine
      • Military Medicine
      • Nanomedicine
      • Net News
      • Neurology
      • Neurosurgery
      • Nuclear Medicine
    • O-P
      • Ob/Gyn
      • Oncology
      • Ophthalmology
      • Orthopedic Surgery
      • Pathology
      • Pediatrics
      • Plastic Surgery
      • Psychiatry
      • Public Health
    • R-V
      • Radiation Oncology
      • Radiology
      • Rehab
      • Reproductive Medicine
      • Space Medicine
      • Sports Medicine
      • Surgery
      • Thoracic Surgery
      • Urology
      • Vascular Surgery
  • SUBSCRIBE
  • Submit PR
  • About
  • Log in
  • Submit PR
  • Follow
    • Facebook
    • Twitter
    • Linkedin
    • Youtube
    • Instagram
    • RSS

Branching a Stent: Interview with Tryton Medical CEO, Shawn McCarthy

June 21st, 2013 Shiv Gaglani Cardiology, Exclusive, Radiology, Vascular Surgery

Tryton Side Branch stentWhen most people in the medical tech field think of stents, they envision a straight (though occluded) atherosclerotic vessel being pushed open via a balloon catheter so that the stent can be placed. But how do you deposit a stent right at the site of a vessel bifurcation, without blocking flow to either of the smaller vessels? Unfortunately, due to turbulent flow around these bifurcations there are often shear forces that can lead to vessel damage and eventually plaque formation. The medical device company Tryton Medical, which we’ve covered before, has a unique stent that is designed for this scenario. We spoke with their CEO Shawn McCarthy to learn more about the technology and market.

Shiv Gaglani, Medgadget: Can you describe the technological innovation behind the stent?

Shawn-McCarthyShawn McCarthy: The Tryton Side Branch Stent™ (Tryton) is an innovative endovascular prosthesis designed for the definitive treatment of coronary artery bifurcations. This device incorporates several technological innovations: the method in which it is utilized is revolutionary; the delivery system is a stepped balloon; and the stent has three unique zones designed specifically for three different portions of the bifurcation.

The Tryton is a balloon-expandable stent manufactured from a single piece of medical grade L-605 cobalt chromium (CoCr) alloy tubing.  This alloy can be formed into thinner stent struts than traditional stainless steel (316L) stents, and provides a more flexible, low profile system while maintaining a balance of adequate radiopacity and strength. The Tryton has a single device that incorporates three distinct zones to treat the side branch, the transition from the side branch to the main vessel, and the proximal main vessel portion of the bifurcation in a single device.  With the Tryton, stent properties such as radial strength, scaffolding, and flexibility are optimized for each zone in order to definitively treat the bifurcation.  Unlike standard coronary stents which look like cylinders, the Tryton looks both cylindrical and conical; matching the underlying geometry of a coronary bifurcation.

The Tryton delivery system is based on a rapid exchange, coronary balloon catheter with several unique features.  The balloon used to deploy the stent has three zones which mate themselves to the three zones on the stent and the corresponding geometry of the bifurcation.  Utilizing a single inflation device all three zones achieve their intended diameter simultaneously.  The delivery system utilizes a four marker delivery system allowing the physician to see the precise location of each zone during device implantation. Finally, this complex catheter meets or exceeds the performance criteria established for standard balloon catheters.

 

Medgadget: How large is the market you’re addressing with the SHORT stent? Can you describe the various use cases?

McCarthy: It’s estimated that 20-30% of all PCI’s (stenting procedures) involve a bifurcation, the majority of which are high risk lesions, which are appropriate side branch stenting candidates.  This equates to the potential for 500,000 annual bifurcation stent procedures globally.   The Tryton Side Branch SHORT stent broadens bifurcation treatment options in large vessels with a SHORT main branch landing zone,  potentially offering a solution for an additional 200,000 procedures annually.

 

Medgadget: What other options are there for these patients?

McCarthy: Current approaches to treating these lesions include provisional balloon angioplasty, primarily focusing on treating disease in the main vessel.  This treatment strategy can be time consuming and technically difficult.  As a result, the side branch is often left unstented, leaving it vulnerable to higher rates of restenosis, the re-narrowing of the artery after intervention.

 

Medgadget: Have clinical trials been performed and, if so, can you discuss the design and results?

McCarthy: Data from more than 1,000 patients collected in 8 registries across Europe treated with the Tryton stent are already challenging provisional stenting, with compelling results of target lesion revascularization of four percent and thrombosis of 0.5 percent at one year.  With more than 7,500 implants to date, we are leveraging our impressive data to further expand globally.

We completed enrollment last November in the landmark Tryton pivotal IDE study, a multi-national randomized trial that compares a Tryton stent in the side branch vs. the use of balloon angioplasty in the side branch, with both arms of the trial utilizing a standard drug eluting stent in the main vessel. The study, which is the first and only randomized IDE pivotal clinical trial evaluating a dedicated bifurcation stent, enrolled 704 patients at centers in North America, Europe and Israel. Martin Leon, M.D. (Columbia University, New York) serves as principal investigator for the study and Patrick Serruys (Thoraxcenter, Rotterdam) is leading IVUS and three-dimensional angiographic analysis.

We anticipate our pivotal IDE results to be presented at the TCT Conference in October 2013, submitted to FDA by end of year, and approved in the US in 2014.  We are on track to be the first and only approved stent for coronary bifurcations in the U.S.

 

Medgadget: What is your background in health tech?

McCarthy: I have more than 20 years of experience commercializing medical device products globally, over half of that time with Johnson & Johnson.  A major focus for me has been to provide minimally invasive solutions for patients suffering from Vascular disease –  across Cardiovascular, Endovascular, and Neurovascular markets.

 

Medgadget: Are you excited by any specific trends in medical innovation/technology?

McCarthy: Medical innovation is going with the grain, meaning startups are taking their businesses further along the maturity curve in a complex business environment – developing devices that generate compelling data, fitting routine physician practice patterns, and offering health economic evidence that suggest an innovative treatment strategy is not only safe and effective, but reasonable and necessary.  Startups demonstrating the ability to navigate sophisticated global regulatory environments quickly and effectively.

 

Product page: Tryton Side Branch Stent…

Shiv Gaglani

Shiv Gaglani is an MD/MBA candidate at the Johns Hopkins School of Medicine and Harvard Business School. In addition to curating the Smartphone Physical (www.smartphonephysical.org), he also contributes regularly to CardioSource World News and Emergency Physicians Monthly. He is interested in developing scalable, tech-based solutions for medicine and education; to this end he is the co-founder of the medical education tech start-up, Osmosis (www.osmosis.org).  More about Shiv: http://about.me/sgaglani

Sponsored
Ark Surgical Performs First Hysterectomies in the USA with its FDA-Cleared LapBox for Manual Morcellation

Ark Surgical Performs First Hysterectomies in the USA with its FDA-Cleared LapBox for Manual Morcellation

PACKAGING COMPLIANCE LABS WELCOMES NEW CFO, BERNADETTE LEGARETTA

PACKAGING COMPLIANCE LABS WELCOMES JENN GOFF, VP SALES, MARKETING, AND INNOVATION

Clarius Debuts its First Dual-Array Wireless Handheld Scanner Enabling Whole-Body Views of Superficial to Deep Anatomy

Clarius Debuts its First Dual-Array Wireless Handheld Scanner Enabling Whole-Body Views of Superficial to Deep Anatomy

National Liver Health Awareness Month Highlights the Urgent Need for Liver Disease Prevention

National Liver Health Awareness Month Highlights the Urgent Need for Liver Disease Prevention

interviews & reviews
A Wearable to Manage Parkinson’s Motor Symptoms: Interview with Lucy Jung, CEO at Charco Neurotech

A Wearable to Manage Parkinson’s Motor Symptoms: Interview with Lucy Jung, CEO at Charco Neurotech

Eko’s Newest CORE 500 Stethoscope: A Review

Eko’s Newest CORE 500 Stethoscope: A Review

Shear-Thinning Biomaterial for Embolic Applications: Interview with Upma Sharma, President and CEO of Arsenal Medical

Shear-Thinning Biomaterial for Embolic Applications: Interview with Upma Sharma, President and CEO of Arsenal Medical

Refillable Device for Drug Delivery Past the Blood-Brain Barrier: Interview with Mike Maglin, CEO at CraniUS

Refillable Device for Drug Delivery Past the Blood-Brain Barrier: Interview with Mike Maglin, CEO at CraniUS

UV-Free Air Decontamination: Interview with Sorel Rothschild, VP at Quantum Innovations

UV-Free Air Decontamination: Interview with Sorel Rothschild, VP at Quantum Innovations

EarliPoint Evaluation System for ASD Diagnosis: Interview with Tom Ressemann, CEO of EarliTec Dx

EarliPoint Evaluation System for ASD Diagnosis: Interview with Tom Ressemann, CEO of EarliTec Dx

Visually Guided Uterine Biopsies in Physician’s Office: Interview with Allison London Brown, CEO of LUMINELLE

Visually Guided Uterine Biopsies in Physician’s Office: Interview with Allison London Brown, CEO of LUMINELLE

  • Subscribe
  • Contact us
  • Submit
  • About
  • Back to top
Medgadget

Medical technologies transform the world! Join us and see the progress in real time. At Medgadget, we report the latest technology news, interview leaders in the field, and file dispatches from medical events around the world since 2004.

  • About
  • Editorial policies
  • Contact
  • Terms of Service
  • Privacy
  • Submit press release
  • Advertise
© Medgadget, Inc. All rights reserved. | The Medical Revolution Will Be Blogged.
Please support this website by adding us to your whitelist in your ad blocker. Ads are what helps us bring you premium content! Thank you!