An interesting tool from CDx Diagnostics (Suffern, NY) is proving effective at identifying dysplasia and Barrett’s Esophagus, potential precursors for esophageal cancer.
The company’s WATS3D (Wide Area Transepithelial Sample biopsy with 3-dimensional analysis) technology collects a more varied sample of tissue than individual pokes using forceps and collects more samples to analyze than cytology. These are then analyzed in 3D throughout the entire sample to spot any signs of disease, a technique that in the latest study showed an “increased detection yield of Barrett’s Esophagus by 20% (9-32%, p < .05). Correlation of WATS3D and forceps biopsy results was uniformly high among all sites with an average concordance index of .88 and a range of .82-.94. In three sites that had more than 30 WATS3D tests performed or had on-site assistance, the increased detection yield of Barrett’s Esophagus was an average of 46% (20%-88%, p < .05, n=75).”
Here’s animation showing how the WATS3D system works: