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Integrated Chemical Chip Could Control Muscle Movement

June 1st, 2012 Brian Klein News

The chip can regulate the delivery of the neurotransmitters such as acetylcholine allowing it to control muscle movement chemically. (Image courtesy of LiU/Ingemar Franzén.)

A new integrated chemical circuit could lead to an array of new applications in life sciences, as it could be used in vivo to regulate the signal paths of cells in the human body. Developed by Klas Tybrandt, doctoral student researching organic electronics at Linköping University (Sweden), the circuits transmit ions and molecules. The chip can work with common signalling substances such as acetylcholine.

Potential applications include sending signals to muscle synapses with a malfunctioning signalling system, says Magnus Berggren, professor of organic electronics at the university. Berggren is also the director of the OBOE Center, a research center focusing on organic bioelectronics.

From the abstract in Nature Communications:

Here we report integrated chemical logic gates based on ion bipolar junction transistors. Inverters and NAND gates of both npn type and complementary type are demonstrated. We find that complementary ion gates have higher gain and lower power consumption, as compared with the single transistor-type gates, which imitates the advantages of complementary logics found in conventional electronics. Ion inverters and NAND gates lay the groundwork for further development of solid-state chemical delivery circuits.

 

Tybrandt and Berggren began to develop ion transistors three years ago that can control and transport ions and charged biomolecules. That research was published in 2010 in Proceedings of the National Academy of Sciences in an article titled “Ion bipolar junction transistors.” A later study titled “Toward Complementary Ionic Circuits: The npn Ion Bipolar Junction Transistor” was published last year in the Journal of the American Chemical Society, which reported the promise of “complementary chemical circuits similar to the electronic equivalence.”

Link: The first chemical circuit developed…

Abstract in Nature Communications: Logic gates based on ion transistors

Brian Klein

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