Curetis AG, Holzgerlingen, Germany, developed a new molecular detection system targeting microorganisms, the Unyvero Solution. It is a nucleic acid multiplex test system intended for the simultaneous detection and identification of nucleic acids associated with a range of bacteria and antibiotic resistances. The system is based on several hardware components and matching disposable cartridges.
The Unyvero Analyzer automates all processes in the cartridge including genomic DNA purification, multiplex nucleic acid amplification with end-point PCR and the detection of the target sequences after hybridization on a special array. The analyzer consists of mechanical, electronic and optical elements to control all sample processing and analysis steps, which happen inside the sealed cartridge. There are two slots that allow the system to process two cartridges independently. All reagents and waste are collected and disposed together with the used cartridge.
A special sample preparation technology is able to gain DNA from many native samples within minutes. It can extract DNA from all kinds of microorganisms (Gram-positive and Gram-negative bacteria, viruses and fungi, mycobacteria and other intracellular organisms) even in complex samples like highly viscous sputa or in samples contaminated with blood.
This month the first developed cartridge, the Unyvero P50, has begun testing in a clinical trial in Europe. It focuses on pathogen as well as antibiotic resistance testing for pneumonia. Each cartridge handles one patient sample and analyzes 39 DNA targets simultaneously. Results are available within less than 4 hours. The first trial results are expected around Spring and another prospective trial is planned in the United States later this year.
Product page: Unyvero Solution…