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St. Jude Medical’s Deep Brain Stimulator Demonstrates Benefit for Parkinson’s Patients

January 12th, 2012 Gavin Corley Neurology, Neurosurgery


The use of implanted Deep Brain Stimulation (DBS) for the treatment of the symptoms of Parkinson’s disease has been the focus of a lot research activity and technological innovation over the last number of years. Yesterday St. Jude Medical announced positive results from a controlled study of their Libra family of DBS implantable pulse generators, the results of which were published in the journal The Lancet Neurology.

The objective of the study was to evaluate the safety and effectiveness of the Libra devices in managing the symptoms of Parkinson’s disease. The study was carried out on on 136 Parkinson’s patients in 15 clinical sites throughout the U.S. and the primary endpoint was an increase in the duration in which patients had good control of their symptoms and motor functions.

The key findings reported in the journal article were as follows:

Both study groups reported a mean increase of good quality on time after 3 months, and the increase was greater in the stimulation group (4·27 h vs 1·77 h, difference 2·51 [95% CI 0·87—4·16]; p=0·003). Unified Parkinson’s disease rating scale motor scores in the off-medication, on-stimulation condition improved by 39% from baseline (24·8 vs 40·8). Some serious adverse events occurred after DBS implantation, including infections in five (4%) of 136 patients and intracranial haemorrhage in four (3%) patients. Stimulation of the subthalamic nucleus was associated with dysarthria, fatigue, paraesthesias, and oedema, whereas gait problems, disequilibrium, dyskinesia, and falls were reported in both groups.

The Libra devices used in this study are essentially constant current pulse generators which deliver a fixed current ‘dose’ irrespective of changes in the properties of the region being stimulated. According to the company website the devices are currently available Europe, Latin America and Australia for managing the symptoms of PD.

Lancet Neurology article: Subthalamic deep brain stimulation with a constant-current device in Parkinson’s disease: an open-label randomised controlled trial doi:10.1016/S1474-4422(11)70308-8

Press release: Results of St. Jude Medical’s First Controlled Study of Deep Brain Stimulation Confirms Benefit of Constant Current System for Patients with Parkinson’s Disease …

Gavin Corley

Gavin holds a first-class Bachelor’s degree in Electronic Engineering degree from the University of Limerick and a Ph.D. in Biomedical Engineering from the National University of Ireland, Galway. He is currently a post-doctoral research and project leader at the NUI Galway where he has spent the last 2 years leading the product development and commercialization of two novel technologies for the management of varicose veins and chronic venous leg ulcers. He has published several research papers in the fields of anatomy, physiology and medical physics and is the lead author of one patent application to date. In his free time Gavin has been known to swim, cycle and hum a tune or two.

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