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Medtronic’s InterStim Therapy Continues to Show Encouraging Results at 3-Year Follow Up

August 16th, 2011 Ronney Shantouf Geriatrics, GI, Rehab, Surgery

The Journal Diseases of the Colon and Rectum recently published data from a multicenter, prospective trial showing that use of Medtronic’s InterStim Therapy via sacral nerve stimulation reduced incontinent episodes and improved quality of life in a majority of patients with chronic fecal incontinence at three years of follow up.  Medgadget reported on the surgically implanted device when the FDA approved commercial distribution of IntreStim for chronic fecal incontinence earlier this year.

The study indicated the long-term effectiveness and safety of InterStim use in patients with fecal incontinence of more than twice per week.  83 of the original 120 patients followed completed all or part of the 3-year follow-up assessment.  At 3 years, 86% of subjects had greater than or equal to 50% reduction in incontinent episodes (mean 9.4 episodes/week reduced to 1.7 episodes/week).  Furthermore 40% of patients had perfect continence. Overall quality of life improved for subjects. The most commonly reported adverse events were implant site pain, paresthesias, stimulation sensation changes, and infection.

The InterStim system is a surgically implanted neurostimulator device that delivers electric impulses via an implanted lead to the sacral nerve to modulate the anal sphincter, and hence incontinence.  The device is similar in function to prior approved stimulation therapy for urinary incontinence.

Press release: Study Shows Medtronic InterStim® Therapy Improves Bowel Control and Related Quality of Life Issues at Three Years …

Abstract: Long-term Efficacy and Safety of Sacral Nerve Stimulation for Fecal Incontinence

Medtronic’s sacral nNeuromodulation info page…

Ronney Shantouf

Ronney Shantouf is a Cardiologist completing his fellowship at Harbor-UCLA and will be specializing in Interventional Cardiology at USC Medical Center. His clinical and research interests include innovative cardiovascular medical technology, coronary artery interventions, acute cardiac care, preventive cardiology, nutrition and exercise, and medical media. He has published on coronary artery disease in the dialysis population, cardiac health in the Middle East, and prior served as the co-founder and editor of the health column in UCLA’s Newspaper The Daily Bruin.

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