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Screening for Diabetes Through Breath Acetone Levels

February 4th, 2011 Sean Duffy Diagnostics

sasz8otc.pngMedical students are always taught about the distinctive, fruity breath of a patient in diabetic ketoacidosis — a life threatening metabolic crisis. The basis of this odor, acetone, is present on all of our breath, but even seemingly healthy diabetics will have a slightly higher level than non-diabetics. Can this subtle difference be used to help detect and screen who’s got diabetes?
Detection of illness through breath analysis is an emerging field in medical diagnostics, and is one which we’ve covered extensively. Sparing a few exceptions, however, the field has yet to make a large impact on patient care. Oxford Medical Diagnostics (OMD), a company that specializes in gas analysis, is attempting to change that through their diabetes screening device based on breath acetone levels that they expect to hit the market in the next six to eight months. Following that, they plan to launch a handheld device in a few years.
From Nebusiness:

Oxford Medical Diagnostics is developing products which give a reading of the levels of acetone in breath when blown into, creating an alternative to the traditional diabetes testing method of pricking a finger and analysing the blood.
A device designed for use by GPs and other medical professionals is expected to hit the market in the next six to eight months after finishing clinical trials, while a more affordable handheld device for home monitoring could be available within a couple of years.

The breakdown of excess Acetyl CoA from fatty acid metabolism in patients with diabetes leads to differences in the levels of acetone in the blood. This acetone is excreted through urine and exhaled through the lungs. For healthy humans, breath acetone concentrations range from .3 to .9 parts per million (ppm) but for those with type two diabetes, concentrations can rise to more than 1.8 parts per million (in type 1 diabetes, these can be much higher still).
Detecting these small differences requires extremely sensitive equipment. The technology behind Oxford Medical’s electronic nose is a type of laser spectroscopy called Cavity Enhanced Absorption Spectroscopy (CEAS), in which laser light bounces back and forth between mirrors so that the overall path length of the light beam extends to a few kilometers. This allows more time for absorption and thus increases the sensitivity of the device.
Nebusiness: Newcastle scientists aiming to create diabetes device
Product page: Oxford Medical Diagnostics
Medgadget electronic nose archives…

Sean Duffy

Sean is the Co-Founder and CEO of Omada Health, (http://omadahealth.com), a Silicon Valley startup that aims brings thoughtful and engaging products to disease prevention and health promotion. Prior to Omada Health, Sean was enrolled in Harvard’s joint MD/MBA program, and previously worked in IDEO’s Health & Wellness group driving innovative work for providers, health technology companies, and employers. Sean also spent two years at Google, served as an editor at Medgadget.com, and was recently named as one of the "40 Under 40" top medtech innovators by MDDI. He received his BS from Columbia University.

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