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CPAP Still Effective for Treating Fatigue Caused by Obstructive Sleep Apnea

January 6th, 2011 Dan Buckland News

Continuous Positive Airway Pressure (CPAP) technologies are a staple at Medgadget (see here, here, here, and here), mostly because they make for good pictures to go with the post. However, they also make for good medicine, as many studies have shown they are effective for everything between reducing heart complications associated with sleep apnea and improving quality of sleep. One of the latest studies in the journal Sleep continues to promote the use of CPAP for Obstructive Sleep Apnea (OSA) by showing in a randomized study that “3 weeks of therapeutic CPAP significantly reduced fatigue and increased energy in patients with OSA”
From the abstract:

Methods:
Fifty-nine men and women with OSA were randomly assigned to therapeutic or placebo CPAP in a double-blind fashion for a 3-week intervention period. Four outcome measures were assessed: (1) fatigue/vigor measured with the Multidimensional Fatigue Symptom Inventory—Short Form (MFSI-sf), the (2) fatigue and (3) vigor subscales of the Profile of Mood States—Short Form (POMS), and (4) the Epworth Sleepiness Scale (ESS). Data were analyzed using repeated-measures analysis of variance.
Results:
Compared with patients receiving placebo CPAP, those patients treated with therapeutic CPAP showed significant reductions in the apnea-hypopnea index, as well as decreases in both measures of fatigue and increases in vigor (P values < 0.05). The beneficial effect of therapeutic treatment was most pronounced in patients with high levels of fatigue at study onset. Significant treatment effects in sleepiness scores were not observed in the entire sample (P > 0.05); however, in a subset of patients with excessive sleepiness at the onset of treatment, ESS scores were significantly reduced with use of therapeutic CPAP (P < 0.05).

Full abstract in Sleep: Effects of Continuous Positive Airway Pressure on Fatigue and Sleepiness in Patients with Obstructive Sleep Apnea: Data from a Randomized Controlled Trial
(via Mass Device)

Dan Buckland

Dan Buckland MD PhD is a Emergency Medicine resident at George Washington University Hospital. He covers space and extreme environment medicine as well as app and gadget reviews. For more information see http://danbuckland.me

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