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New NasoNeb Trials May Offer Better Medication Delivery

October 25th, 2010 Haroon Anwar ENT

MedInvent, LLC out of White Bear Lake, MN has developed the NasoNeb, a large particle nasal nebulizer (LPNN) system, in an effort to enhance sino-nasal drug delivery. Two recently reported studies at the American Rhinologic Society meeting suggest this unique delivery system offers improved delivery of medication via aerosolized droplets into open sinuses.
From the abstract titled “A Comparative Study of the Distribution of Normal Saline Delivered by Large
Particle Nebulizer vs. Large Volume/Low Pressure Squeeze Bottle”
:

Results: Fluorescein staining was higher than baseline for both LPNN and LVLP devices. No difference between LPNN and LVLP was noted, but a trend favoring LVLP at the frontal recess/sinus was observed. For LVLP, a fixed concentration produced statistically significant greater fluorescein staining at all sites. For a fixed amount of dye, LPNN scored better than the LVLP at the ethmoid sinuses and olfactory cleft.
Conclusions: Both LPNN and LVLP delivered dye to all sites. The LPNN may offer advantages in the delivery of high concentrations of drug in relatively small volumes. LVLP may provide greater drug delivery at the frontal recess/sinus. The practical significance of these observations is unclear, but further investigation seems warranted.

From another abstract::

Results: The irrigator consistently delivered aerosolized saline to the ANC, MM/EC and SER/SS across the 3 trials. A statistically significant increase in delivery was noted in the MS+EC compared to the MM (p=0.044) post ESS. In addition, a statistically significant increase in delivery to the F-NEO was noted relative to the FS post EML (p=0.001). Multiplicity adjustment done for the ESS group showed statistical superior delivery to the EC vs OC (p=0.031) and FS (p=0.02) and the SS vs FS (0.031).
Multiplicity adjustment after EML improved delivery to the FS resulting in no statistical difference in aerosol delivery between F-NEO and EC or SS.
Conclusions: The novel irrigator device consistently delivered aerosolized saline to multiple nasal subsites, with improvement in delivery seen to the F-NEO after EML. This has important implications for the delivery of topical medications to the paranasal sinuses and frontal neo-ostium.

Check out this video from their website for more information.


Product page: NasoNeb…
Study abstracts: “A Comparative Study of the Distribution of Normal Saline Delivered by Large Particle Nebulizer vs. Large Volume/Low Pressure Squeeze Bottle”
“Prospective Evaluation of a Novel Powered Nasal Irrigator Device in the Post-FESS Cadaver Model”

Haroon Anwar

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