VectorBlog, the new medtech blog from Children’s Hospital Boston that we recently mentioned is already breaking news from the CHB labs. In yesterday’s posting they report on a new paper in Cell Stem Cell that details “[a] new way to reprogram ordinary human cells into stem cells, using RNAs, appears safer and much more efficient than current methods – and can much more readily transform stem cells into specialized cells to treat disease.”
From the paper highlights:
Modified mRNAs can express reprogramming proteins and evade antiviral response Highly efficient derivation of human iPSCs without genomic integration RNA-derived iPSCs faithfully recapitulate the properties of human ESCs Efficient directed differentiation of iPSCs to differentiated myotubes
VectorBlog: A game-changing advance in regenerative medicine…
Full Article in Cell Stem Cell: Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA