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New Trial Will Test Efficacy of Spinal Cord Stimulation in Treating Heart Failure

July 29th, 2010 Smit Shah Cardiology

Medtronic announced today the start of its Defeat-HF study, in which the company will attempt to treat heart failure through the use of spinal cord stimulation (SCS). Trial subjects will be implanted with Medtronic’s PrimeADVANCED neurostimulation device, which is currently being used for pain management. The treatment’s efficacy will be evaluated based on heart size, muscle wall thickness, fatigue, shortness of breath, and quality of life improvements.
An explanation from Medtronic’s press release:

Heart failure stimulates the sympathetic nervous system further progressing the disease. The Defeat-HF study will evaluate whether SCS can restore the natural balance between the sympathetic and parasympathetic nervous systems to improve blood flow, reduce inflammation and restore the heart’s dimensions and function. The study will be conducted under an Investigational Device Exemption (IDE) in the United States.
The prospective, randomized, feasibility trial is expected to enroll NYHA Class III systolic heart failure patients at up to 15 centers worldwide. All patients are implanted with a Medtronic PrimeADVANCED™ neurostimulator and followed for 12 months. In this trial, the device delivers stimulation for 12 hours a day.

Press release: Medtronic Launches Novel Clinical Trial Evaluating Spinal Cord Stimulation Therapy for Heart Failure…
Product page: PrimeAdvanced Neurostimulator…
Flashback: RestoreADVANCED™, PrimeADVANCED™ Neurostimulators

Smit Shah

Smit Shah is a biomedical engineer currently working as a consulting analyst at Accenture. He has a Masters in Engineering Management from Duke University. When not working, he enjoys cooking, concerts, and exploring New York City.

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