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Scientists Directly Record Neural Activity in Flying Drosophila

February 18th, 2010 Medgadget Editors News

Caltech researchers are reporting that they developed a technique for performing whole-cell patch-clamp recordings from specific neurons in behaving Drosophila. That’s right: behaving, breathing, flying melanogasters. Such research can open many new frontiers in our understanding of neurophysiology.
Caltech explains:

Researchers at the California Institute of Technology (Caltech) have obtained the first recordings of brain-cell activity in an actively flying fruit fly.
The work—by Michael Dickinson, the Esther M. and Abe M. Zarem Professor of Bioengineering, with postdoctoral scholars Gaby Maimon and Andrew Straw—suggests that at least part of the brain of the fruit fly (Drosophila melanogaster) "is in a different and more sensitive state during flight than when the fly is quiescent," Dickinson says…
In particular, the researchers focused on those neurons in the fly’s visual system that keep the animal flying stably. "These cells basically help the fly detect when its body posture changes," Dickinson says. "The signals from these cells are thought to control tiny steering muscles that then change the pattern of wing motion and bring the animal back into equilibrium."
In their experiments, the researchers discovered that when the animals began to fly, the visual cells immediately ramped up their activity. "The neurons’ responses to visual motion roughly double when the flies begin to fly, which suggests that the system is more sensitive during flight," Dickinson says. "The increase is very abrupt. It’s not at all a subtle change, and so we suspect that there is a neurochemical quickly released during flight that sets the animal’s brain in this different state."
Previous studies in locusts—which are far bigger and thus far easier to study—had suggested the existence of this effect. However, the genetics of locusts are not nearly as well understood as those of Drosophila, which has made it impossible to pinpoint the genetic basis for the phenomenon.
In Drosophila, Dickinson says, it now should be possible to "figure out specifically what causes the change in sensitivity. Is the system turned off when the fly is on the ground? What neurochemicals are involved? Now we can start to use the genetic tricks that are available in fruit flies to get a better idea of what is going on."
Maimon adds "Our work on Drosophila is of general interest because sensory neurons in many species—including birds, rodents, and primates—change their response strength depending on the behavioral state of the animal, but why these changes in sensitivity take place is not entirely clear."
In addition, the researchers plan to use their tethered-flight system to record the activity of other types of cells, including olfactory and motor cells, to determine if these also behave differently during flight and when flies are at rest.
"The question is, ‘Is the entire brain completely different in flight?’" Dickinson says. "We suspect that this phenomenon is not unique to the visual cells we have studied. Most cells care whether the animal is flying or not."

Abstract in Nature Neuroscience: Active flight increases the gain of visual motion processing in Drosophila
Full story: Caltech Researchers Obtain First Brain Recordings from Behaving Fruit Flies…

Medgadget Editors

Medical technologies transform the world! Join us and see the progress in real time. At Medgadget, we report the latest technology news, interview leaders in the field, and file dispatches from medical events around the world since 2004.

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