In a presentation to the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), that sounds eerily similar to some of our sci-fi essay contest submissions, researchers from the Mayo Clinic described a new method they are developing to help diagnose endocarditis. The researchers utilized neural networks to analyze clinical data and determine whether or not patients had endocarditis. If the patient had a low probability of infection he/she would not require any further testing, avoiding costly trans-esophageal ultrasounds.
Here is more information from the press release:
Endocarditis — an infection involving the valves and sometimes chambers of the heart — can be a problem in patients with implanted medical devices. It is serious and can be deadly. The mortality rate can be as high as one in five, even with aggressive treatment and removal of the device. With additional complications, the mortality could be over 60 percent. Diagnosis usually requires transesophageal echocardiography, an invasive procedure that also has risks. It involves use of an endoscope and insertion of a probe down the esophagus.
The software program is called an "artificial neural network" (ANN) because it mimics the brain’s cognitive function and reacts differently to situations depending on its accumulated knowledge. That knowledge or training is provided by researchers, similar to how a person would "train" a computer to play chess, by introducing it to as many situations as possible. In this case, the ANN underwent three separate "trainings" to learn how to evaluate the symptoms it would be considering.
The team studied 189 Mayo patients with device-related endocarditis diagnosed between 1991 and 2003. The ANN was tested retrospectively on the data from these cases. When tested on cases with known diagnosis of endocarditis, the best-trained ANN was correct most of the time (72 of 73 implant-related infections and 12 of 13 endocarditis cases) with a confidence level greater than 99 percent.
Read the press release here…
