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Lasers and Nanoparticles Team Up to Target Tumor Cells

September 10th, 2009 Medgadget Editors Nanomedicine


Scientists at University of California, Santa Barbara have developed a gene silencing technique that uses a combination of gold nanoshells and siRNA (silencing ribonucleic acid) conjugates for delivery. A low energy laser is then used to activate and release the siRNA at the specific site of a tumor where treatment is needed.

The scientists used cancer cells from mice, and grew them in culture. They then introduced gold nanoshells, with a peptide-lipid coating, that encapsulated “silencing ribonucleic acid” (siRNA), which was the drug that was taken up by the cells. Next, they exposed the cells to a non-harmful infrared laser.
“A major technical hurdle is how to combine multiple biochemical components into a compact nanoparticle which may be taken up by cells and exist stably until the release is desired,” said Gary Braun, first author and a graduate student in UCSB’s Department of Chemistry and Biochemistry. “Laser-controlled release is a convenient and powerful tool, allowing precise dosing of particular cells within a group. The use of biologically friendly tissue penetration with near-infrared light is the ideal for extending this capability into larger biological systems such as tissues and animals.”
The authors demonstrated, for the first time, the delivery of a potent siRNA cargo inside mammalian cancer cells, released by exposing the internalized nanoparticles for several seconds to a pulsed near-infrared laser tuned for peak absorption with a specific spatial pattern. The technique can be expanded to deliver numerous drug molecules against diverse biological targets.


Press release: UCSB Researchers Develop Drug Delivery System Using Nanoparticles and Lasers
Abstract in ACS NANO: Laser-Activated Gene Silencing via Gold Nanoshell-siRNA Conjugates

Medgadget Editors

Medical technologies transform the world! Join us and see the progress in real time. At Medgadget, we report the latest technology news, interview leaders in the field, and file dispatches from medical events around the world since 2004.

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