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New Developments for DNA Nanomachines

April 16th, 2009 Medgadget Editors Nanomedicine

The promise of DNA nanomachines that can change shape due to specific triggers, and in such a way create complicated systems, is not a new notion. In the latest edition of Nature Nanotechnology, Indian scientists are reporting the development of an interesting DNA pH sensor, a DNA nanomachine that “maps spatial and temporal pH changes inside living cells.”
Nanowerk explains:

"We named our DNA nanomachine the I-switch" Yamuna Krishnan tells Nanowerk. "The device is externally triggered by protons and functions as a pH sensor based on fluorescence resonance energy transfer (FRET) inside living cells. We demonstrate the ability of this DNA nanomachine to function inside living cells by using it to map spatio-temporal pH changes associated with endosome maturation. Our studies show that it is able to function as efficiently inside the endosome of a living cell as it does in a test tube."
Krishnan is a scientist at the National Centre for Biological Sciences in Bangalore, India, where she heads the Chemical Biology Group. The DNA assembly developed by her team is a robust pH-triggered nanoswitch with reasonably fast response times, sustained efficiency over several cycles, and a working cycle that does not generate toxic byproducts (the byproducts of a complete cycle for the I-switch are salt and water).
The I-switch has a pH sensitivity between pH 5.5 and 6.8 – which is ideal for monitoring changes in intracellular pH – and offers complementary information to that obtained through the use of small-molecule fluorescent pH probes. Krishnan points out that, unlike such pH probes, the I-switch is a FRET-based sensor that is equally bright at both physiological and acidic values of pH.

More from Nanowerk…
Abstract: A DNA nanomachine that maps spatial and temporal pH changes inside living cells
Image: Drosophila cells with the I-switch inside their endosomes. (Image: Dr. Krishnan, National Centre for Biological Sciences)

Medgadget Editors

Medical technologies transform the world! Join us and see the progress in real time. At Medgadget, we report the latest technology news, interview leaders in the field, and file dispatches from medical events around the world since 2004.

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