Michael Berger of Nanowerk is profiling research of scientists at the Indian Institute of Technology which aims to resolve some of the issues with building functional and effective drug delivery nanoparticles.
That engineered nanomaterials, especially inorganic ones, will be used for nanomedicine applications has now become a certainty. However, the use of these nanomaterials should occur with detailed knowledge of delivery, fate and functioning at the target, and finally release from the body. And that’s an area where a lot of unanswered questions remain.
In particular, the question of what happens if (and that still often is a big if) the drug-containing nanoparticles reach their intended target is a crucial one: How do the drug molecules get released from the delivery vehicle? In other words, how does the ‘envelope’ get opened? What is the fate of the nanoparticles (drugs as well as containers) post opening? New work done by scientists in India is contributing to how the nanoscience community is tackling these issues.
Researchers from the Indian Institute of Technology Guwahati present experimental results which suggest that the specificity of release of encapsulated nanoparticles could be achieved with an appropriate combination of encapsulating materials and the choice of an appropriate enzyme that would cleave the encapsulation to release the nanoparticles.
More from Nanowerk…
Article abstract: Probing Au Nanoparticle Uptake by Enzyme Following the Digestion of a Starch-Au-Nanoparticle Composite
Image: Schematic representation of the proposed mechanism of gold nanoparticle transfer from the starch-gold nanoparticle composite to the enzyme. The 3D structure of Î±-amylase is retrieved from Protein Data Base (PDB) entry 1DHK.