In the upcoming issue of BioMed Central’s open access journal Critical Care, investigators from University of Cambridge and University Paris-Sud will report that the thickness of the optic nerve sheath is a good marker for raised intracranial pressure (ICP), when imaged by a T2-weighted MRI.
From a press statement by BioMed Central:
The dural sheath surrounding the optic nerve communicates with the subarachnoid space and distends when ICP is elevated. Thomas Geeraerts, from Addenbrooke’s Hospital, Cambridge, led a team who investigated whether MRI can be used to precisely measure the diameter of the optic nerve and its sheath. He said, “Raised ICP is frequent in conditions such as stroke, liver failure and meningitis. It is associated with increased mortality and poor neurological outcomes. As a result, the early detection and treatment of raised ICP is critical, but often challenging. Our MRI-based technique provides a useful, non-invasive solution”.
The early detection of raised ICP can be very difficult when invasive devices are not available. As the authors report, “Clinical signs of raised ICP such as headache, vomiting and drowsiness are not specific and are often difficult to interpret. In sedated patients, clinical signs frequently appear well after the internal damage has been done. Optic nerve sheath distension could be an early, reactive and sensitive sign of raised ICP”.
The authors carried out a retrospective blinded analysis of brain MR images in a prospective cohort of 38 patients requiring ICP monitoring after traumatic brain injury and 36 healthy controls. Geeraerts said, “We found that ONSD measurement was able to provide a quantitative estimate of the likelihood of significant cranial hypertension”.
Press release: New marker for raised intracranial pressure…
Paper: Use of T2-weighted magnetic resonance imaging of the optic nerve sheath to detect raised intracranial pressure (.pdf)
Image credit: Wellcome images: Magnetic resonance image (MRI), T2 weighted axial scan of 5-year-old male with an acquired squint caused by brain stem glioma….