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Scientists Create Biomolecular Movies

April 16th, 2008 Medgadget Editors Genetics


Investigators from the Argonne National Laboratory, using the Advanced Photon Source, an X-ray synchrotron covered by us many times before, were able to reconstruct real motions of biological molecules in solutions. Pictured above is animation of the molecular structure of porphyrin changing along “with a calculated X-ray scattering pattern that corresponds to the structure of a light-harvesting porphyrin array.”

Biological and organic molecules in solution are far more complex than the standard crystalline structures of salt or metals since they are constantly moving and changing over time. These motions have not yet been seen directly, but scientists using the high-intensity X-rays at the Advanced Photon Source have measured images that are "blurred" by these motions and have used them to create more accurate movies of molecular motions.
Computer simulations are currently the only way to visualize molecular motions in solution, but researchers have not had a means to check the accuracy of these simulations for complex molecules. For the first time, scientists can see the movements first hand and compare them to their theoretical counterparts.
" The blurring that we see in our solution X-ray patterns are remarkably sensitive to the type of the molecular motion," senior chemist David Tiede said. "For the first time, we are able to test the accuracy of the simulation and change it to fit data better. Without it, we had no way of knowing how accurate the models were."
Tiede hopes an improved accuracy in molecular modeling will give insights into the structure and behavior of the molecules. Collaborators at the National Institutes of Health have used this approach to help determine structures of important biological molecules.
Tiede and his collaborators also plan to examine how a structure reacts to an outside stimulus. By using a laser to excite the atoms, he will create a movie that shows how the molecule reacts to the initial laser pulse and also how it returns to a stable condition.
"We hope to establish between’good’ and’bad’ molecular actors in important chemical processes like photosynthesis, solar energy and catalysts," Tiede said. "Once we see that, we can make these processes work better."

Press release: Argonne scientists develop techniques for creating molecular movies…

Medgadget Editors

Medical technologies transform the world! Join us and see the progress in real time. At Medgadget, we report the latest technology news, interview leaders in the field, and file dispatches from medical events around the world since 2004.

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