Investigators at New York University and Tel Aviv University have developed a non-invasive MRI-based imaging modality to quantify the concentration of glycosaminogycans (GAGs) in vivo, opening the possibility of using this technology for early diagnosis of such conditions as osteoarthritis and inter-vertebral disc degeneration. A group under NYU Chemistry Professor Alexej Jerschow is reporting their research findings in the latest Proceedings of the National Academy of Sciences:
…the existing techniques for GAG monitoring-based on traditional magnetic resonance imaging (MRI)-have limitations: they cannot directly map GAG concentrations or they require the administration of contrast agents. The NYU-Tel Aviv research team sought a more direct measurement of GAGs. In this study, they employed the exchangeable protons of GAG to directly measure GAG concentration in vivo.
Knowing that GAG molecules have proton groups that are not tethered tightly, the researchers investigated whether proton exchange in GAGs could allow concentrations of the molecule to be measured by the MRI. By separating out the GAG protons from those of water, they can be used as a sort of inherent contrast agent. Testing the idea in tissue samples, the researchers found that the available GAG protons provided an effective type of contrast enhancement, allowing them to readily monitor GAGs through a clinical MRI scanner. The in vivo application of this method showed that this technique can be readily implemented in a clinical setting.
This chemical exchange saturation method (gagCEST) not only could provide a non-invasive way to diagnose osteoarthritis in its very early stages, but could also help to indicate early interventions for degenerative disc disease, which is responsible for lower back pain, and defects in heart valves and, potentially, the cornea.
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