Investigators from the Oak Ridge National Laboratory are working together with Las Vegas-based NMT, Inc. to miniaturize, and make wireless, the company’s impedance-based hydration monitor:
While Noninvasive Medical Technologies has a ZOE on the market, used primarily in home health care applications, the company’s goal was to improve upon the product by making it more robust, smaller, less expensive and able to be monitored remotely.
DeMarr said her company sought out ORNL because of its expertise and stellar reputation in the areas of chip design. The project has progressed rapidly as Britton and Ericson, members of the lab’s Engineering Science and Technology Division, began work about a year ago and clinical trials for the new device were completed last month.
“Our key contributions were to reduce the system to an integrated circuit, or chip, to reduce the amount of power needed to operate the unit and to lower the cost,” Ericson said.
“Before we could do that, however, as a team we had to better understand the product as a circuit that has to operate in a wide range of temperatures yet maintain a high degree of accuracy,” Britton said.
The ZOE Fluid Status Monitor measures thoracic base impedance, which is a measurement of the electric current traveling from the top to the bottom of the thorax. This is accomplished by placing one electrode at the top and another at the bottom of the breastbone. The less resistance – measured in ohms – the more fluid in the chest. The normal range for people is between 19 ohms and 30 ohms. Values lower than 19 indicate that a person may be overhydrated while values exceeding 30 indicate dehydration.
“The measurement is a quick and easy method to determine whether a person is experiencing fluid congestion or dehydration,” DeMarr said. “Studies have shown that Zo, or the base resistance, is an early predictor of congestion in heart failure, showing decreases as early as two weeks prior to weight gain and other symptoms.”
ORNL press release: Nevada company, ORNL develop potential lifesaver
ZOE product page…