Jennifer Timpe et al from the McKeating Laboratory at the Institute for Biomedical Research at the University of Birmingham uncovered a previously unknown mode of Hep C transmission.
From the statement by the UK’s Medical Research Council:
Scientists looking for an effective treatment for Hepatitis C may face an even bigger task than anticipated. Recent studies looking into how the virus spreads in liver tumour cells have demonstrated that the virus uses two different routes, which may explain why the body’s natural occurring antibodies are ineffective at controlling the virus.
… the virus does not need to be released by a cell before infecting the next one, but can slip directly from one to the other and avoid the body’s neutralizing antibodies or medical attempts to boost antibody production. They have also found that the direct cell-to-cell route can transmit virus infectivity independently of a co-receptor molecule called CD81, previously reported to be essential for extracellular virus infection of a cell.
Jennifer Timpe, the lead author on the paper who presented the study at the recent 14th International Symposium on Hepatitis C Virus in Glasgow, explains: “Viruses can spread by two different mechanisms: via extracellular virus particles or direct cell-to-cell transfer. Until now, HCV was thought to spread by extracellular viruses infecting cells, a route vulnerable to antibodies. But our research shows the virus to uses both mechanisms to get around. This is probably why it has been so tricky to tackle.” These latest results seem to indicate, from laboratory tests, that the virus’ dramatic spread in acute Hep C cases may result from cell-to-cell transfer which appears to be a faster mechanism for the virus to infect new target cells.
Jennifer Timpe concludes “Finding that Hep C uses multiple mechanisms for spreading around the body was not great news, but this discovery will allow those of us working in this area to move ahead with a better understanding of the virus. We will have to up our game and find other ways of tackling this relentless virus. Future studies will investigate the pathways of cell-cell transfer of infectivity which may reveal new targets for antiviral therapy.”
Press release: Hepatitis C virus found to spread directly from cell to cell by-passing antibodies …
The paper @ Hepatology: Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies …
