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Scientists Alter Sexual Orientation in Worms, Create In-Petri Dish Homosexuals

October 26th, 2007 Medgadget Editors News

Biologists at the University of Utah subjected nerve cells of tiny nematode worms C. elegans to laser microsurgery, and stumbled on a mechanism to change the animals’ sexual orientation. The investigators believe that their clever experiments show that sexual orientation is indeed hardwired in the brain:

“They look like girls, but act and think like boys,” says Jamie White, a postdoctoral researcher and first author of the new study. “The [same-sex attraction] behavior is part of the nervous system.”
The study was published online Thursday, Oct. 25 in Current Biology, and will run in the journal’s Nov. 6 print edition…
Nematodes, or C. elegans, are millimeter-long (one twenty-fifth of an inch) worms that live in soil and eat bacteria. Because the same genes are found in many animals, nematodes, mice, zebrafish and fruit flies often are used as “models” for humans in research.
Nematode worms lack eyes, so attraction is based only on the sense of smell. There are no true females and only one in 500 nematodes is male. Most are hermaphrodites, with both male and female organs. Jorgensen and White loosely refer to hermaphrodites as females because they produce offspring.
“A hermaphrodite makes both eggs and sperm,” Jorgensen says. “She doesn’t need to mate [with a male] to have progeny,” but can fertilize her own eggs. “Most of the time, the hermaphrodites do not mate. But if they mate, instead of having 200 progeny, they can have 1,200 progeny…”
Jorgensen says the study looked at three possibilities, namely, whether male attraction to hermaphrodites results from:

  • Four “accessory” or extra smell-related nerve cells named CEM neurons that are found only in male brains. The worms gain these neurons during their version of puberty, their fourth larval stage.
  • Four “core” or basic smell-related nerve cells – two named AWC and two named AWA – found in both males and hermaphrodites.
  • Both the accessory and core neurons.
  • The answer was that male attraction involves the combination of both accessory and core nerve cells…
    The study involved these key experiments:

  • The researchers used laser microsurgery to kill the male-only CEM neurons in young larval males. The resulting adult males still were attracted to hermaphrodites.
    That suggests the core neurons – brain cells common to both the male and hermaphrodite brain – are sexualized, and that the extra CEM nerve cells found only in males are not necessary for sexual attraction even though they normally play a role in it.
  • The biologists zapped eight different kinds of nerve cells involved in the sense of smell and taste: the four kinds of CEM neurons found only in males and four kinds of core neurons (AWA and AWC) also found in hermaphrodites. If any of the eight types of neurons was damaged in adult males, attraction was impaired. But when the nerve cells were zapped before puberty in fourth-stage larvae, they grew into adults with normal attraction to hermaphrodites. That shows “the nervous system can compensate for lost neurons as it goes through puberty,” Jorgensen says.
    “Normally there are eight sensory neurons in nematodes,” says White. “You can take away seven of the eight prior to sexual maturation, and as long as there is one left, he can still be sexually attracted. … Why would an organism that has only 383 nerve cells use eight of them for sexual attraction? It must be that the behavior is very important. There is redundancy. The system is flexible.”
  • Next, “we took the hermaphrodite brain and we activated the genes that determine maleness,” but only in the brain and not in the rest of the worm, Jorgensen says. Hermaphrodites with masculine brains “were attracted to other hermaphrodites.”
    The results show sexual orientation is wired into the brain in both sexes of worm.
  • To masculinize the brains of hermaphroditic worms, the researchers activated a gene named fem-3, but only in the nervous system. The fem-3 gene makes the body develop male structures such as a tail, which male worms use for copulation. With the gene active only in the brain, the hermaphrodites still had the same bodies and genitalia, but their brains were male, so they were attracted to other hermaphrodites.
    To demonstrate the hermaphrodites produce sexual attractants or pheromones, the researchers washed hermaphrodites, and put some of the wash water on agar, a jelly-like growth medium, in a culture dish. When worms were placed on the dish, males moved toward the hermaphrodite wash water while hermaphrodites moved away.
    When the scientists genetically altered hermaphrodites’ brains to change their sexual orientation, they crawled toward the pheromones of other hermaphrodites.

    Press release: SCIENTISTS ALTER SEXUAL ORIENTATION IN WORMS …

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