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Hexasaccharide Promise as a Novel Antibiotic

October 8th, 2007 Medgadget Editors News


A group of Japanese scientists, taking lesson from the pathophysiology of Helicobacter pylori, set out on a course to develop a possibly novel type of antibacterial compound:

A team of Japanese scientists led by Shino Manabe from the RIKEN Discovery Research Institute, Wako, has synthesized an oligosaccharide with antibiotic activity…
A few years ago, it was discovered that, although the bacterium prospers on the surface of the stomach lining, deeper down in the membrane its growth is suppressed. It was proposed that a glycoprotein, a protein with saccharide side chains, was responsible by effectively inhibiting the synthesis of a compound needed by the bacterium to form cell membranes. Upon investigation this glycoprotein was shown to consist of an unusually branched hexasaccharide believed crucial for this behavior.
With existing methods to synthesize this molecule producing only small amounts of material, Manabe realized the importance of being able to make larger quantities to allow for more detailed studies. Therefore, her team set about designing and preparing an efficient strategy to produce the hexasaccharide as presented in a recent paper published in the Journal of Organic Chemistry1. The structure proved a challenge because a particular part of the saccharide needs to be arranged in an uncommon way where two adjoining groups are on the same side of the molecule instead of on opposite sides, known as a 1,2-cis linkage.
Overall the synthetic route developed by the team gave good yields in an efficient way allowing for greater quantities of material to be obtained. Manabe’s strategy has an additional benefit: the way in which the researchers have synthesized the compound means making derivatives will be straightforward. Following the success of this project, the team is now focusing on using their approach to synthesize various oligosaccharides and investigate their potential biological activity.

Full statement from RIKEN Institute: A new route to synthesize an antibiotic may also lead to new drugs …

Medgadget Editors

Medical technologies transform the world! Join us and see the progress in real time. At Medgadget, we report the latest technology news, interview leaders in the field, and file dispatches from medical events around the world since 2004.

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