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Seeing Nano Propellers of the Future

July 19th, 2007 Medgadget Editors Nanomedicine

In a way similar to bacteria that use the flagella to swim to a desired location, the delivery of medicines, packaged in nanovesicles, or other nanostructures, may one day depend on molecular-sized motors. A research group of Dr. Petr Král at the University of Illinois at Chicago studies the design and modeling of nanoscale systems, and they now believe that they “created a theoretical blueprint for assembling a nanoscale propeller with molecule-sized blades.”

The work is featured in Research Highlights in the July 12 issue of Nature and was described in the June 28 cover story of Physical Review Letters.
Using classical molecular dynamics simulations, Petr Král, assistant professor of chemistry at UIC, and his laboratory coworkers were able to study realistic conditions in this microscopic environment to learn how the tiny propellers pump liquids.
While previous research has looked at how molecular devices rotate in flowing gases, Král and his group are the first to look at molecular propeller pumping of liquids, notably water and oils.
“We want to see what happens when the propellers get to the scale where it’s impossible to reduce the size of the blades any more,” said Král.
Král’s group found that at the molecular level — unlike at the macro level — the chemistry of the propeller’s blades and their sensitivity to water play a big role in determining whether the propeller pumps efficiently or just spins with little effect. If the blades have a hydrophobic, or water-repelling nature, they pump a lot of water. But if they are hydrophilic — water-attracting — they become clogged with water molecules and pump poorly.
“Pumping rates and efficiencies in the hydrophilic and hydrophobic forms can differ by an order of magnitude, which was not expected,” he said.
The UIC researchers found that propeller pumping efficiency in liquids is highly sensitive to the size, shape, chemical or biological composition of the blades.
“In principle, we could even attach some biological molecules to the blades and form a propeller that would work only if other molecules bio-compatible with the blades are in the pumped solution,” he said.
The findings present new factors to consider in developing nanoscale liquid-pumping machines, but Král added that such technology probably won’t become reality for several years, given the difficult nature of constructing such ultra-small devices.
Král’s laboratory studies how biological systems, like tiny flagella that move bacteria, offer clues for building motors, motile systems and other nanoscale devices in a hybrid environment that combines biological and inorganic chemistry.

Press release: Nano Propellers Pump with Proper Chemistry …
Petr Král’s Design and Modeling of Nanoscale Systems Group

Medgadget Editors

Medical technologies transform the world! Join us and see the progress in real time. At Medgadget, we report the latest technology news, interview leaders in the field, and file dispatches from medical events around the world since 2004.

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