Researchers from UC Santa Barbara, UC Berkley and in collaboration with California based StrataGent Life Sciences, developed a novel pulsed microject system engineered for protein drug delivery without any needle pain. Here’s an excerpt from UCSB:
The researchers felt that the pain and bruising caused by previously-developed jet injectors was caused by the deep penetration of jets into the skin, creating negative reactions of nerves and capillaries. The pulsed mircrojets engineered by the researchers combine high velocity (more than 100 meters per second) with very small jet diameters (between 50 and 100 micrometers), delivering only 2 to 15 nanoliters of liquid drug at a time. The research showed that the pulsed microjet system could be used to effectively deliver drugs for local and systemic applications without using needles.
“The microjet system delivers precise doses into superficial skin layers, thereby mitigating pain,” says Samir Mitragotri, a professor of chemical engineering at UCSB and a lead author of the paper. The system was designed as an alternative to the macro-scale systems that had been causing pain and bruising. “We realized that we had to find a way to stop the jets from going deep into the skin,” says Mitragotri. “Speeding the delivery, combined with using extremely small jet diameters and less liquid per pulsation, was shown to be more effective.”