An international team of investigators, studying the genetic causes of type 2 diabetes, have identified four genes that increase the risk of developing the disease.
From Imperial College London news release:
The researchers identified four loci, or points on individuals’ genetic maps, which corresponded to a risk of developing the disorder. The scientists, from Imperial College London, McGill University, Canada, and other international institutions, believe their findings explain up to 70% of the genetic background of type-2 diabetes.
In addition, one of the genetic mutations which they detected might further explain the causes behind type-2 diabetes, potentially leading to new treatments. The research revealed that people with type-2 diabetes have a mutation in a particular zinc transporter known as SLC30A8, which is involved in regulating insulin secretion. Type-2 diabetes is associated with a deficiency in insulin and the researchers believe it may be possible to treat it by fixing this transporter.
Professor Philippe Froguel New Window, one of the authors of the study from the Division of Medicine at Imperial College London, said: “If we can tell someone that their genetics mean they are pre-disposed towards type-2 diabetes, they will be much more motivated to change things such as their diet to reduce their chances of developing the disorder. We can also use what we know about the specific genetic mutations associated with type-2 diabetes to develop better treatments.”
The scientists reached their conclusions after comparing the genetic makeup of 700 people with type-2 diabetes and a family history of the condition, with 700 controls. They looked at mutations in the building blocks, called nucleotides, which make up DNA.
There are mutations in around one in every 600 nucleotides and the scientists examined over 392,000 of these mutations to find the ones specific to type-2 diabetes. The mutations are known as single-nucleotide polymorphisms.
The researchers confirmed their findings by analysing the genetic makeup of a further 5,000 individuals with type-2 diabetes and a family history of the disorder, to verify that the same genetic mutations were visible in these individuals.
Imperial College London news release…
Update: Centre National de la Recherche Scientifique: Elucidation of the genome for diabetics with DNA chips