• Popular
    • Medicine
    • Radiology
    • Cardiology
    • Surgery
    • Nanomedicine
    • Military Medicine
    • Rehab
  • Categories
    • Exclusive
    • A-D
      • Anesthesiology
      • Art
      • Cardiac Surgery
      • Cardiology
      • Critical Care
      • Dentistry
      • Dermatology
      • Diagnostics
    • E-I
      • Emergency Medicine
      • ENT
      • Genetics
      • Geriatrics
      • GI
      • Informatics
    • M-N
      • Medicine
      • Military Medicine
      • Nanomedicine
      • Net News
      • Neurology
      • Neurosurgery
      • Nuclear Medicine
    • O-P
      • Ob/Gyn
      • Oncology
      • Ophthalmology
      • Orthopedic Surgery
      • Pathology
      • Pediatrics
      • Plastic Surgery
      • Psychiatry
      • Public Health
    • R-V
      • Radiation Oncology
      • Radiology
      • Rehab
      • Reproductive Medicine
      • Space Medicine
      • Sports Medicine
      • Surgery
      • Thoracic Surgery
      • Urology
      • Vascular Surgery
  • SUBSCRIBE
  • Submit PR
  • About
  • Follow
    • Facebook
    • Twitter
    • Linkedin
    • Youtube
    • Instagram
    • RSS
  • Submit PR
  • Log in
Medgadget
Medgadget
  • Popular
    • Medicine
      Flexible Sensors Detect Heavy Metals in Sweat

      Flexible Sensors Detect Heavy Metals in Sweat

      Nanopore Sensor to Study Protein Aggregation in Neurodegeneration

      Nanopore Sensor to Study Protein Aggregation in Neurodegeneration

      Biobots Use Optogenetic Muscle Actuators for Movement

      Biobots Use Optogenetic Muscle Actuators for Movement

      Exciting Medtech at the Healthcareᐩ Expo Taiwan

      Exciting Medtech at the Healthcareᐩ Expo Taiwan

    • Radiology
      Ultrasound Tornado Rapidly Disrupts Blood Clots

      Ultrasound Tornado Rapidly Disrupts Blood Clots

      Exciting Medtech at the Healthcareᐩ Expo Taiwan

      Exciting Medtech at the Healthcareᐩ Expo Taiwan

      Fluorescence Imaging System Illuminates Tumor Depth

      Fluorescence Imaging System Illuminates Tumor Depth

      Soft Robot Grows Like a Plant to Travel Through Tight Spaces

      Soft Robot Grows Like a Plant to Travel Through Tight Spaces

    • Cardiology
      Belt Monitors Heart Failure Patients

      Belt Monitors Heart Failure Patients

      Camera Measures Blood Pressure with Quick Look

      Camera Measures Blood Pressure with Quick Look

      Monitoring Congestive Heart Failure Through Speech: Interview with Tamir Tal, CEO of Cordio Medical

      Monitoring Congestive Heart Failure Through Speech: Interview with Tamir Tal, CEO of Cordio Medical

      Device Measures Hemoglobin More Accurately in Dark Skin

      Device Measures Hemoglobin More Accurately in Dark Skin

    • Surgery
      Microneedle Bandage for Hemostatic Control

      Microneedle Bandage for Hemostatic Control

      Biobots Use Optogenetic Muscle Actuators for Movement

      Biobots Use Optogenetic Muscle Actuators for Movement

      Implantable Device Adheres to Muscle, Treats Atrophy

      Implantable Device Adheres to Muscle, Treats Atrophy

      Device Measures Hemoglobin More Accurately in Dark Skin

      Device Measures Hemoglobin More Accurately in Dark Skin

    • Nanomedicine
      Extra Hot Nanoparticles for Cancer Therapy

      Extra Hot Nanoparticles for Cancer Therapy

      Making Tumors Tastier for the Immune System

      Making Tumors Tastier for the Immune System

      Improved Membrane Coating for Anti-Cancer Nanoparticles

      Improved Membrane Coating for Anti-Cancer Nanoparticles

      Magnetic Bacteria Target Tumors

      Magnetic Bacteria Target Tumors

    • Military Medicine
      Device Measures Hemoglobin More Accurately in Dark Skin

      Device Measures Hemoglobin More Accurately in Dark Skin

      Fingertip Sensor Measures Lithium Levels in Sweat

      Fingertip Sensor Measures Lithium Levels in Sweat

      Fabric Makes Electricity from Movement to Power Wearables

      Fabric Makes Electricity from Movement to Power Wearables

      Wearable Uses Microneedles to Track Metabolism

      Wearable Uses Microneedles to Track Metabolism

    • Rehab
      Smart Walking Stick for Visually Impaired People

      Smart Walking Stick for Visually Impaired People

      Implantable Device Adheres to Muscle, Treats Atrophy

      Implantable Device Adheres to Muscle, Treats Atrophy

      Non-Invasive Spinal Modulation for Cerebral Palsy

      Non-Invasive Spinal Modulation for Cerebral Palsy

      Implanted Magnets for Prosthetic Control

      Implanted Magnets for Prosthetic Control

  • Categories
    • Exclusive
    • A-D
      • Anesthesiology
      • Art
      • Cardiac Surgery
      • Cardiology
      • Critical Care
      • Dentistry
      • Dermatology
      • Diagnostics
    • E-I
      • Emergency Medicine
      • ENT
      • Genetics
      • Geriatrics
      • GI
      • Informatics
    • M-N
      • Medicine
      • Military Medicine
      • Nanomedicine
      • Net News
      • Neurology
      • Neurosurgery
      • Nuclear Medicine
    • O-P
      • Ob/Gyn
      • Oncology
      • Ophthalmology
      • Orthopedic Surgery
      • Pathology
      • Pediatrics
      • Plastic Surgery
      • Psychiatry
      • Public Health
    • R-V
      • Radiation Oncology
      • Radiology
      • Rehab
      • Reproductive Medicine
      • Space Medicine
      • Sports Medicine
      • Surgery
      • Thoracic Surgery
      • Urology
      • Vascular Surgery
  • SUBSCRIBE
  • Submit PR
  • About
  • Log in
  • Submit PR
  • Follow
    • Facebook
    • Twitter
    • Linkedin
    • Youtube
    • Instagram
    • RSS

Immunity That’s More Than Skin Deep

January 29th, 2007 Josh Umbehr Pediatrics


One of the tricky issues involved in vaccinating the public from a highly communicable disease is the “public” part. How do you quickly administer the vaccine to people without increasing the risk of rapidly spreading the illness in question? Well, the geniuses at the Iomai Company have devised a technology that would enable vaccines to be mailed to the masses and self administered.
From the Washington Post:

Executives at Iomai Corp. see the future of flu vaccinations like this: A small patch containing the vaccine, along with stimulants to make it more potent, is mailed to patients who stick the patch to their arms for a few hours, then toss it in the trash.
It is a far off but potentially paradigm-shifting approach to vaccination, and last week federal health officials gave their strongest indication yet that Iomai’s patch technology has broad public-health possibilities. To stretch the vaccine supply for pandemic flu should an outbreak occur, the Department of Health and Human Services awarded the Gaithersburg company, founded in 1997, a contract worth as much as $128 million to develop both the patch and the immune-system stimulant it contains.

Company’s transcutaneous immunization (TCI) technology explained:

In 1998, Dr. Gregory Glenn, published a paper in the journal Nature, detailing how he and a team from Walter Reed Army Institute of Research were able to stimulate an impressive immune response in mice using transcutaneous immunization (TCI) technology.
TCI delivers vaccine or immune stimulating adjuvants to a group of cells in the skin called Langerhans cells that are a part of the immune system and have been shown to produce a robust immune response. In his conclusion, Dr. Glenn predicted that the work “may ultimately lead to the development of simple and safe needle-free vaccines…”
TCI effectively stimulates the body’s immune system to bring about the immune response required for protection against disease. Potent immune stimulants (adjuvants) are delivered at the surface of the skin to the Langerhans cells, a major component of the immune system. The Langerhans cells, activated by the presence of these immune stimulants, take in the vaccine antigen and migrate to the regional draining lymph nodes. There, presentation to the immune system occurs, eliciting a robust immune response.
Compared to standard immunization via needles, two important features of TCI pave the way for more effective vaccines:

  • TCI follows the natural pathway for protection by targeting the immune-rich epidermis, which is replete with Langerhans cells.
  • Because there is no systemic exposure, strong immune stimulants can be used safely on the skin, stimulating a powerful immune response.
  • Full article at the Washington Post . . .
    Product Page . . .
    (hat tip: Book of Joe)

    Josh Umbehr

    Josh Umbehr, MD founded AtlasMD Concierge Family Practice, one of the fastest growing insurance-free practices in the country. Currently developing an industry leading platform for direct primary care physicians: Atlas EMR Software for Concierge Medicine.

    Sponsored
    C-mo Medical Solutions extends seed investment round to €4.8 million to transform cough monitoring

    C-mo Medical Solutions extends seed investment round to €4.8 million to transform cough monitoring

    New Clarius Power Fan HD3 Delivers a First for Handheld Ultrasound: Continuous Scanning

    New Clarius Power Fan HD3 Delivers a First for Handheld Ultrasound: Continuous Scanning

    Fluidx Unveils New Embolic for Neurovascular Use

    Fluidx Unveils New Embolic for Neurovascular Use

    Annalise.ai and Nuance Communications (a Microsoft Company) Announce Key Partnership to Improve Patient Outcomes with Workflow-Integrated AI

    Annalise.ai and Nuance Communications (a Microsoft Company) Announce Key Partnership to Improve Patient Outcomes with Workflow-Integrated AI

    PT Genie Unveils New Brand Identity Reflecting Company’s Transformation and Focus on the Global Future of AI and Machine Learning in Digital Healthcare

    interviews & reviews
    Balance Boards to Stay Active in the Offfice: Interview with Joel Heath, CEO of FluidStance 

    Balance Boards to Stay Active in the Offfice: Interview with Joel Heath, CEO of FluidStance 

    Exciting Medtech at the Healthcareᐩ Expo Taiwan

    Exciting Medtech at the Healthcareᐩ Expo Taiwan

    Medgadget Visits Healthcareᐩ Expo Taiwan

    Medgadget Visits Healthcareᐩ Expo Taiwan

    Diabetes Management Tech for Type II patients: Interview with Jeffrey Brewer, CEO of Bigfoot Biomedical

    Diabetes Management Tech for Type II patients: Interview with Jeffrey Brewer, CEO of Bigfoot Biomedical

    Monitoring Congestive Heart Failure Through Speech: Interview with Tamir Tal, CEO of Cordio Medical

    Monitoring Congestive Heart Failure Through Speech: Interview with Tamir Tal, CEO of Cordio Medical

    In-Office Pediatric Ear Tube Procedures: Interview with Preceptis Medical's Greg Mielke

    In-Office Pediatric Ear Tube Procedures: Interview with Preceptis Medical's Greg Mielke

    Symani Microsurgical Robotic System: Interview with Mark Toland, CEO of Medical Microinstruments

    Symani Microsurgical Robotic System: Interview with Mark Toland, CEO of Medical Microinstruments

    • Subscribe
    • Contact us
    • Submit
    • About
    • Back to top
    Medgadget

    Medical technologies transform the world! Join us and see the progress in real time. At Medgadget, we report the latest technology news, interview leaders in the field, and file dispatches from medical events around the world since 2004.

    • About
    • Editorial policies
    • Contact
    • Terms of Service
    • Privacy
    • Submit press release
    • Advertise
    © Medgadget, Inc. All rights reserved. | The Medical Revolution Will Be Blogged.
    Please support this website by adding us to your whitelist in your ad blocker. Ads are what helps us bring you premium content! Thank you!
    Posting....
    • Facebook
    • Twitter
    • LinkedIn
    • Reddit
    • Email