A group of researchers at the Washington University School of Medicine in St. Louis has demonstrated that metabolism of hearts of patients with left ventricular hypertrophy (LVH) is skewed away from the use of fat for energy. These findings complement the research that the same group has conducted earlier on diabetics, which has shown increased myocardial dependence on fat.
De las Fuentes [Lisa de las Fuentes, M.D. is a co-director of the Cardiovascular Imaging and Clinical Research Core Laboratory and assistant professor of medicine –ed.] explains that hearts with muscle thickening, or hypertrophy, get less energy because of their reduced fat metabolism, which leads them to rely more heavily on carbohydrates.
“Carbohydrates produce less energy per molecule than fatty acids,” she says. “With hypertrophy, the heart has a higher energy demand because there’s more muscle to feed. With less fat metabolism, a greater reliance on carbohydrates may represent a shift to a less-efficient fuel.”
The metabolic abnormality can eventually lead to impaired contraction of the heart and to heart failure.
Animal studies by collaborators at Washington University have shown that in mice with thickened heart muscle, genes associated with transporting and breaking down fatty acids are less active than normal — in other words, the heart’s fat-burning machinery is malfunctioning.
In this human study, the researchers studied patients who had high blood pressure that resulted in hypertrophy of the muscle of the left ventricle, the chamber of the heart that pumps blood to the body. The study showed that the greater the muscle mass of the hypertrophic heart, the lower the ability to burn fat. Magnetic resonance scans suggested that hypertrophic heart muscle had subtle abnormalities in contractile function at rest and was less energy efficient.
Normally heart muscle will alter between using fats and carbohydrates as fuel depending on availability. But at times of the day when blood glucose is low – such as when a person hasn’t eaten in a while – hypertrophic hearts can’t switch to burning fatty acids as normal hearts would, possibly leaving them energy deficient, de las Fuentes explains.
“This is the first time these data have been shown in humans,” says senior author Victor G. Davila-Roman, M.D., director of the Cardiovascular Imaging and Clinical Research Core Laboratory and professor of medicine, anesthesiology and radiology. “That is particularly significant because hypertension (high blood pressure) is a huge public health problem in the United States. Of the 65 million people with hypertension, between 25 and 50 percent of them have some evidence that their heart has been affected by high blood pressure.”
Not everyone who has high blood pressure will develop hypertrophy, and not everyone with hypertrophy has long-term problems, according to de las Fuentes. Some people appear to be protected while others appear to be at increased risk, likely due to genetic factors.
“Because we have this evidence that shows that fatty acid metabolism may play a role in this process, we are looking for variations in the metabolism genes in an ongoing clinical study,” de las Fuentes says.
Link at the Washington University School of Medicine…
