Embolotherapy with Smart Bubbles

Investigators out of the University of Michigan have developed a process of using gas bubbles for cancer embolization. Moreover, they controlled where the bubbles were formed, minimizing the damage to healthy surrounding tissue:

In traditional embolotherapy techniques, the so-called cork that doctors use to block the blood flow–called an emboli–is solid. For instance, it could be a blood clot or a gel of some kind. A major difficulty with these approaches is restricting the emboli to the tumor to minimize destruction of surrounding tissue, without extremely invasive procedures, Bull said. [Joseph Bull is an assistant professor of biomedical engineering at UMich -ed.] The emboli must be delivered by a catheter placed into the body at the tumor site.
Gas bubbles, on the other hand, allow very precise delivery because their formation can be controlled and directed from the outside, by a focused high intensity ultrasound.
This envisioned technique is actually a two-step process, Bull said. First, a stream of encapsulated superheated perfluorocarbon liquid droplets goes into the body by way of an intravenous injection. The droplets are small enough that they don’t lodge in vessels. Doctors image the droplets with standard ultrasound, and once the droplets reach their destination, scientists hit them with high intensity ultrasound. The ultrasound acts like a pin popping a water balloon. After the shell pops, the perfluorocarbon expands into a gas bubble that is approximately 125 times larger in volume than the droplet.
“If a bubble remained spherical its diameter would be much larger than that of the vessel,” Bull said. “So it deforms into a long sausage-shaped bubble that lodges in the vessel like a cork. Two or three doses of bubbles will occlude most of the (blood) flow.” Without blood flow, the tumor dies.
Because the bubble is so big, it’s critical to get the right vessel in order not to damage it.
“How flexible the vessel is plays a very important role in where you do this,” Bull said. That is the subject of a paper coming out on gas embolotherapy in the August issue of the Journal of Biomechanical Engineering…
The technique could be very valuable in treating certain cancers, such as renal cancer and hepatocellular carcinoma, the most common form of liver cancer, causing about 1,250,000 deaths annually. However, cirrhosis of the liver makes it difficult to treat by the conventional method of removing the tumor and surrounding tissue, because so much of the liver is already damaged. This cancer has a high mortality rate.

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